InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Actr3

Summary

InnateDB Gene

IDBG-188705.7

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Actr3

Gene Name

ARP3 actin-related protein 3

Synonyms

1200003A09Rik; Arp3

Species

Mus musculus

Ensembl Gene

ENSMUSG00000026341

Encoded Proteins

IDBP-188707

ARP3 actin-related protein 3 homolog (yeast)

IDBP-716721

IDBP-790429

ARP3 actin-related protein 3

IDBP-790430

ARP3 actin-related protein 3

IDBP-790431

ARP3 actin-related protein 3

IDBP-790432

ARP3 actin-related protein 3

IDBP-790434

ARP3 actin-related protein 3

IDBP-790435

ARP3 actin-related protein 3

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000115091:
The specific function of this gene has not yet been determined; however, the protein it encodes is known to be a major constituent of the ARP2/3 complex. This complex is located at the cell surface and is essential to cell shape and motility through lamellipodial actin assembly and protrusion. Three transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Mar 2013]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 1:125392905-125435727

Strand

Reverse strand

Band

E2.3

Transcripts

ENSMUST00000027579	ENSMUSP00000027579
ENSMUST00000178474	ENSMUSP00000137503
ENSMUST00000186008
ENSMUST00000191578	ENSMUSP00000139886
ENSMUST00000188362
ENSMUST00000189192
ENSMUST00000188497	ENSMUSP00000140535
ENSMUST00000191544	ENSMUSP00000139674
ENSMUST00000191004	ENSMUSP00000140953
ENSMUST00000187460	ENSMUSP00000140000
ENSMUST00000185280	ENSMUSP00000140082
ENSMUST00000188827

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 20 experimentally validated interaction(s) in this database.
They are also associated with 33 interaction(s) predicted by orthology.

Experimentally validated
Total	20 [view]
Protein-Protein	20 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	33 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003779	actin binding
GO:0005515	protein binding
GO:0005524	ATP binding

Biological Process

GO:0007163	establishment or maintenance of cell polarity
GO:0008356	asymmetric cell division
GO:0009743	response to carbohydrate
GO:0010592	positive regulation of lamellipodium assembly
GO:0016344	meiotic chromosome movement towards spindle pole
GO:0030838	positive regulation of actin filament polymerization
GO:0033206	cytokinesis after meiosis
GO:0043519	regulation of myosin II filament organization
GO:0045666	positive regulation of neuron differentiation
GO:0046677	response to antibiotic
GO:0050775	positive regulation of dendrite morphogenesis
GO:0051321	meiotic cell cycle
GO:0051491	positive regulation of filopodium assembly
GO:0051653	spindle localization
GO:0060271	cilium morphogenesis

Cellular Component

GO:0000139	Golgi membrane
GO:0002102	podosome
GO:0005737	cytoplasm
GO:0005884	actin filament
GO:0005911	cell-cell junction
GO:0016020	membrane
GO:0030027	lamellipodium
GO:0030056	hemidesmosome
GO:0031252	cell leading edge
GO:0060076	excitatory synapse
GO:0070062	extracellular vesicular exosome