InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Pik3r6

Summary

InnateDB Protein

IDBP-188804.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Pik3r6

Protein Name

phosphoinositide-3-kinase, regulatory subunit 6

Synonyms

BB220380; p84; p84 PIKAP; p87(PIKAP); p87PIKAP;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000052522

InnateDB Gene

IDBG-188800 (Pik3r6)

Protein Structure

UniProt Annotation

Function

Regulatory subunit of the PI3K gamma complex. Acts as an adapter to drive activation of PIK3CG by beta-gamma G protein dimers. The PIK3CG:PIK3R6 heterodimer is much less sensitive to beta-gamma G proteins than PIK3CG:PIK3R5 and its membrane recruitment and beta-gamma G protein dimer-dependent activation requires HRAS bound to PIK3CG. Recruits of the PI3K gamma complex to a PDE3B:RAPGEF3 signaling complex involved in angiogenesis; signaling seems to involve RRAS. {ECO:0000269PubMed:15797027, ECO:0000269PubMed:16476736, ECO:0000269PubMed:19906996}.

Subcellular Localization

Cytoplasm. Membrane; Peripheral membrane protein.

Disease Associations

Tissue Specificity

Highly expressed in heart. In a lower extent, also expressed in brain, spleen, lung, liver, kidney, prostate, thyroid, salivary gland, dendritic cells, macrophages and neutrophils. {ECO:0000269PubMed:16476736}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.

Experimentally validated
Total	5 [view]
Protein-Protein	5 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0046934	phosphatidylinositol-4,5-bisphosphate 3-kinase activity
GO:0046935	1-phosphatidylinositol-3-kinase regulator activity

Biological Process

GO:0001525	angiogenesis
GO:0007186	G-protein coupled receptor signaling pathway
GO:0043406	positive regulation of MAP kinase activity
GO:0043551	regulation of phosphatidylinositol 3-kinase activity
GO:0045766	positive regulation of angiogenesis
GO:0046854	phosphatidylinositol phosphorylation