InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Clspn

Summary

InnateDB Protein

IDBP-188970.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Clspn

Protein Name

claspin homolog (Xenopus laevis)

Synonyms

Species

Mus musculus

Ensembl Protein

ENSMUSP00000045344

InnateDB Gene

IDBG-188964 (Clspn)

Protein Structure

UniProt Annotation

Function

Required for checkpoint mediated cell cycle arrest in response to inhibition of DNA replication or to DNA damage induced by both ionizing and UV irradiation. Adapter protein which binds to BRCA1 and the checkpoint kinase CHEK1 and facilitates the ATR- dependent phosphorylation of both proteins. Can also bind specifically to branched DNA structures and may associate with S- phase chromatin following formation of the pre-replication complex (pre-RC). This may indicate a role for this protein as a sensor which monitors the integrity of DNA replication forks (By similarity). {ECO:0000250}.

Subcellular Localization

Nucleus {ECO:0000250}. Chromosome {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 23 interaction(s) predicted by orthology.

Experimentally validated
Total	3 [view]
Protein-Protein	2 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	23 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003677	DNA binding
GO:0005515	protein binding
GO:0010997	anaphase-promoting complex binding

Biological Process

GO:0000077	DNA damage checkpoint
GO:0006281	DNA repair
GO:0018105	peptidyl-serine phosphorylation
GO:0031572	G2 DNA damage checkpoint
GO:0032147	activation of protein kinase activity
GO:0033314	mitotic DNA replication checkpoint