Version 5.4
Mus musculus Gene: Clspn
Summary
InnateDB Gene IDBG-188964.7
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Clspn
Gene Name claspin
Synonyms
Species Mus musculus
Ensembl Gene ENSMUSG00000042489
Encoded Proteins
IDBP-188970
claspin homolog (Xenopus laevis)
IDBP-542623
claspin homolog (Xenopus laevis)
IDBP-537801
claspin homolog (Xenopus laevis)
IDBP-535271
claspin homolog (Xenopus laevis)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000092853:
The product of this gene is an essential upstream regulator of checkpoint kinase 1 and triggers a checkpoint arrest of the cell cycle in response to replicative stress or DNA damage. The protein is also required for efficient DNA replication during a normal S phase. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 4:126556935-126593903
Strand Forward strand
Band D2.2
Transcripts
ENSMUST00000048391 ENSMUSP00000045344
ENSMUST00000147675 ENSMUSP00000116699
ENSMUST00000123695
ENSMUST00000129795 ENSMUSP00000120683
ENSMUST00000126512 ENSMUSP00000119437
ENSMUST00000146944
ENSMUST00000128202
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 23 interaction(s) predicted by orthology.
Experimentally validated
Total 3 [view]
Protein-Protein 2 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 23 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003677 DNA binding
GO:0005515 protein binding
GO:0010997 anaphase-promoting complex binding
Biological Process
GO:0000077 DNA damage checkpoint
GO:0006281 DNA repair
GO:0018105 peptidyl-serine phosphorylation
GO:0031572 G2 DNA damage checkpoint
GO:0032147 activation of protein kinase activity
GO:0033314 mitotic DNA replication checkpoint
Cellular Component
GO:0005634 nucleus
GO:0005694 chromosome
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000092853
View Gene Order
ENSBTAG00000002826
Not yet available
Pathways
NETPATH
REACTOME
REACT_258521
Apoptosis pathway
REACT_224460
Apoptotic cleavage of cellular proteins pathway
REACT_188804
Cell Cycle pathway
REACT_256025
Cell Cycle Checkpoints pathway
REACT_235397
G2/M Checkpoints pathway
REACT_232236
Activation of ATR in response to replication stress pathway
REACT_207035
Apoptotic execution phase pathway
KEGG
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_6769
Activation of ATR in response to replication stress pathway
REACT_107
Apoptotic cleavage of cellular proteins pathway
REACT_995
Apoptotic execution phase pathway
REACT_828
G2/M Checkpoints pathway
REACT_578
Apoptosis pathway
REACT_115566
Cell Cycle pathway
REACT_1538
Cell Cycle Checkpoints pathway
KEGG
INOH
PID NCI
atr_pathway
ATR signaling pathway
plk1_pathway
PLK1 signaling events
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Mm.243962 Mm.394329
RefSeq NM_175554
OMIM
CCDS CCDS18655
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca