InnateDB Protein
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IDBP-188975.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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Tarbp2
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Protein Name
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TAR (HIV) RNA binding protein 2
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Synonyms
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Prbp; TRBP;
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Species
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Mus musculus
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Ensembl Protein
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ENSMUSP00000023813
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InnateDB Gene
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IDBG-188971 (Tarbp2)
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Protein Structure
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Function |
Required for formation of the RNA induced silencing complex (RISC). Component of the RISC loading complex (RLC), also known as the micro-RNA (miRNA) loading complex (miRLC), which is composed of DICER1, AGO2 and TARBP2. Within the RLC/miRLC, DICER1 and TARBP2 are required to process precursor miRNAs (pre-miRNAs) to mature miRNAs and then load them onto AGO2. AGO2 bound to the mature miRNA constitutes the minimal RISC and may subsequently dissociate from DICER1 and TARBP2. May also play a role in the production of short interfering RNAs (siRNAs) from double-stranded RNA (dsRNA) by DICER1 (By similarity). Binds in vitro to the PRM1 3'-UTR. Seems to act as a repressor of translation. {ECO:0000250, ECO:0000269PubMed:8649414}.
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Subcellular Localization |
Cytoplasm {ECO:0000255HAMAP-Rule:MF_03034, ECO:0000269PubMed:8649414}. Cytoplasm, perinuclear region {ECO:0000255HAMAP-Rule:MF_03034}. Nucleus {ECO:0000255HAMAP- Rule:MF_03034, ECO:0000269PubMed:8649414}.
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Disease Associations |
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Tissue Specificity |
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 21 interaction(s) predicted by orthology.
Experimentally validated |
Total |
1
[view]
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Protein-Protein |
1
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
21 [view]
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Molecular Function |
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Biological Process |
GO:0006417
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regulation of translation
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GO:0030422
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production of siRNA involved in RNA interference
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GO:0030423
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targeting of mRNA for destruction involved in RNA interference
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GO:0031054
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pre-miRNA processing
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GO:0035280
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miRNA loading onto RISC involved in gene silencing by miRNA
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GO:0045070
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positive regulation of viral genome replication
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GO:0046782
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regulation of viral transcription
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GO:0050689
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negative regulation of defense response to virus by host
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Cellular Component |
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PDB ID |
MGI:103027
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InterPro |
IPR014720
Double-stranded RNA-binding domain
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PFAM |
PF00035
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PRINTS |
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PIRSF |
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SMART |
SM00358
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TIGRFAMs |
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Modification |
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SwissProt |
P97473
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PhosphoSite |
PhosphoSite-P97473
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TrEMBL |
D3Z282
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UniProt Splice Variant |
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Entrez Gene |
21357
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UniGene |
Mm.291485
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RefSeq |
NP_033345
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MGI ID |
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MGI Symbol |
Tarbp2
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OMIM |
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CCDS |
CCDS27886
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HPRD |
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IMGT |
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EMBL |
AC137156
BC002028
CH466550
U79962
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GenPept |
AAB38885
AAH02028
EDL03967
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