InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Tarbp2

Summary

InnateDB Gene

IDBG-188971.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Tarbp2

Gene Name

TAR (HIV) RNA binding protein 2

Synonyms

Prbp; TRBP

Species

Mus musculus

Ensembl Gene

ENSMUSG00000023051

Encoded Proteins

IDBP-188973

TAR (HIV) RNA binding protein 2

IDBP-188975

TAR (HIV) RNA binding protein 2

IDBP-534475

TAR (HIV) RNA binding protein 2

IDBP-541178

TAR (HIV) RNA binding protein 2

IDBP-534030

TAR (HIV) RNA binding protein 2

IDBP-538685

TAR (HIV) RNA binding protein 2

IDBP-537290

TAR (HIV) RNA binding protein 2

IDBP-538892

TAR (HIV) RNA binding protein 2

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000139546:
HIV-1, the causative agent of acquired immunodeficiency syndrome (AIDS), contains an RNA genome that produces a chromosomally integrated DNA during the replicative cycle. Activation of HIV-1 gene expression by the transactivator Tat is dependent on an RNA regulatory element (TAR) located downstream of the transcription initiation site. The protein encoded by this gene binds between the bulge and the loop of the HIV-1 TAR RNA regulatory element and activates HIV-1 gene expression in synergy with the viral Tat protein. Alternative splicing results in multiple transcript variants encoding different isoforms. This gene also has a pseudogene. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 15:102518192-102523676

Strand

Forward strand

Band

Transcripts

ENSMUST00000100168	ENSMUSP00000097744
ENSMUST00000023813	ENSMUSP00000023813
ENSMUST00000131184	ENSMUSP00000117964
ENSMUST00000141266
ENSMUST00000136968
ENSMUST00000150393	ENSMUSP00000120315
ENSMUST00000154451
ENSMUST00000142114	ENSMUSP00000114953
ENSMUST00000154948
ENSMUST00000134033
ENSMUST00000146756	ENSMUSP00000121748
ENSMUST00000149200	ENSMUSP00000123213
ENSMUST00000142194	ENSMUSP00000123339
ENSMUST00000153171

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 21 interaction(s) predicted by orthology.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	21 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003725	double-stranded RNA binding
GO:0005515	protein binding
GO:0035197	siRNA binding
GO:0035198	miRNA binding
GO:0042803	protein homodimerization activity

Biological Process

GO:0006417	regulation of translation
GO:0030422	production of siRNA involved in RNA interference
GO:0030423	targeting of mRNA for destruction involved in RNA interference
GO:0031054	pre-miRNA processing
GO:0035280	miRNA loading onto RISC involved in gene silencing by miRNA
GO:0045070	positive regulation of viral genome replication
GO:0046782	regulation of viral transcription
GO:0050689	negative regulation of defense response to virus by host