InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Chd4

Summary

InnateDB Protein

IDBP-189060.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Chd4

Protein Name

chromodomain helicase DNA binding protein 4

Synonyms

9530019N15Rik; AA617397; BC005710; D6Ertd380e; Mi-2beta; mKIAA4075;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000060054

InnateDB Gene

IDBG-189058 (Chd4)

Protein Structure

UniProt Annotation

Function

Component of the histone deacetylase NuRD complex which participates in the remodeling of chromatin by deacetylating histones. {ECO:0000269PubMed:17938210}.

Subcellular Localization

Nucleus {ECO:0000250}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000250}. Note=Associates with centrosomes in interphase. {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 40 experimentally validated interaction(s) in this database.
They are also associated with 70 interaction(s) predicted by orthology.

Experimentally validated
Total	40 [view]
Protein-Protein	38 [view]
Protein-DNA	1 [view]
Protein-RNA	1 [view]
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	70 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000978	RNA polymerase II core promoter proximal region sequence-specific DNA binding
GO:0000980	RNA polymerase II distal enhancer sequence-specific DNA binding
GO:0001103	RNA polymerase II repressing transcription factor binding
GO:0003676	nucleic acid binding
GO:0003677	DNA binding
GO:0004386	helicase activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0008017	microtubule binding
GO:0008026	ATP-dependent helicase activity
GO:0008134	transcription factor binding
GO:0008270	zinc ion binding
GO:0016787	hydrolase activity
GO:0016818	hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides
GO:0031492	nucleosomal DNA binding

Biological Process

GO:0006200	ATP catabolic process
GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0016568	chromatin modification
GO:0043044	ATP-dependent chromatin remodeling
GO:0051225	spindle assembly

Cellular Component

GO:0000790	nuclear chromatin
GO:0005634	nucleus
GO:0005654	nucleoplasm
GO:0005737	cytoplasm
GO:0005813	centrosome
GO:0016020	membrane
GO:0016581	NuRD complex
GO:0043234	protein complex

Protein Structure and Domains

PDB ID

MGI:1344380

InterPro

IPR000330 SNF2-related
IPR000953 Chromo domain/shadow
IPR001650 Helicase, C-terminal
IPR001965 Zinc finger, PHD-type
IPR006935 Helicase/UvrB domain
IPR009057 Homeodomain-like
IPR009071 High mobility group box domain
IPR009462 Domain of unknown function DUF1086
IPR009463 Domain of unknown function DUF1087
IPR011011 Zinc finger, FYVE/PHD-type
IPR012957 CHD, C-terminal 2
IPR012958 CHD, N-terminal
IPR014001 Helicase, superfamily 1/2, ATP-binding domain
IPR016197 Chromo domain-like
IPR019787 Zinc finger, PHD-finger
IPR021006 Histone deacetylase complex, subunit 2/3
IPR023780 Chromo domain
IPR027417 P-loop containing nucleoside triphosphate hydrolase

PFAM