InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Calcoco1

Summary

InnateDB Protein

IDBP-189183.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Calcoco1

Protein Name

calcium binding and coiled coil domain 1

Synonyms

1810009B06Rik; Cocoa; Gcap11; mKIAA1536;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000023818

InnateDB Gene

IDBG-189181 (Calcoco1)

Protein Structure

UniProt Annotation

Function

Functions as a coactivator for aryl hydrocarbon and nuclear receptors (NR). Recruited to promoters through its contact with the N-terminal basic helix-loop-helix-Per-Arnt-Sim (PAS) domain of transcription factors or coactivators, such as NCOA2. During ER-activation acts synergistically in combination with other NCOA2-binding proteins, such as EP300, CREBBP and CARM1. Involved in the transcriptional activation of target genes in the Wnt/CTNNB1 pathway. Functions as a secondary coactivator in LEF1- mediated transcriptional activation via its interaction with CTNNB1. Coactivator function for nuclear receptors and LEF1/CTNNB1 involves differential utilization of two different activation regions. {ECO:0000269PubMed:14690606, ECO:0000269PubMed:16931570}.

Subcellular Localization

Cytoplasm {ECO:0000269PubMed:16931570}. Nucleus {ECO:0000269PubMed:16931570}. Note=Shuttles between nucleus and cytoplasm.

Disease Associations

Tissue Specificity

Expressed in all tissues examined except spleen, with high levels of expression in the heart and kidney. {ECO:0000269PubMed:14690606, ECO:0000269PubMed:15522220}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 14 interaction(s) predicted by orthology.

Experimentally validated
Total	2 [view]
Protein-Protein	2 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	14 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003682	chromatin binding
GO:0003712	transcription cofactor activity
GO:0003713	transcription coactivator activity
GO:0005515	protein binding
GO:0008013	beta-catenin binding
GO:0008022	protein C-terminus binding
GO:0030374	ligand-dependent nuclear receptor transcription coactivator activity
GO:0043565	sequence-specific DNA binding
GO:0044212	transcription regulatory region DNA binding
GO:0070016	armadillo repeat domain binding

Biological Process

GO:0006351	transcription, DNA-templated
GO:0007165	signal transduction
GO:0016055	Wnt signaling pathway
GO:0030518	intracellular steroid hormone receptor signaling pathway
GO:0045893	positive regulation of transcription, DNA-templated
GO:0045944	positive regulation of transcription from RNA polymerase II promoter