InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Taf8

Summary

InnateDB Protein

IDBP-189218.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Taf8

Protein Name

TAF8 RNA polymerase II, TATA box binding protein (TBP)-associated factorq

Synonyms

AW260255; Tbn;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000063201

InnateDB Gene

IDBG-189216 (Taf8)

Protein Structure

UniProt Annotation

Function

Transcription factor TFIID is one of the general factors required for accurate and regulated initiation by RNA polymerase II. Mediates both basal and activator-dependent transcription. Plays a role in the differentiation of preadipocyte fibroblasts to adipocytes, however does not seem to play a role in differentiation of myoblasts. Required for the integration of TAF10 in the TAF complex (By similarity). May be important for survival of cells of the inner cell mass which constitute the pluripotent cell population of the early embryo. {ECO:0000250, ECO:0000269PubMed:11076765, ECO:0000269PubMed:14580349}.

Subcellular Localization

Nucleus {ECO:0000269PubMed:11076765}. Cytoplasm {ECO:0000269PubMed:11076765}. Note=Localized in the cytoplasm and transported from the cytoplasm to the nucleus in some cells, possibly depending on the functional or developmental state of the cell.

Disease Associations

Tissue Specificity

Low level of expression throughout the brain with slightly higher expression in the hippocampus.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 14 interaction(s) predicted by orthology.

Predicted by orthology
Total	14 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0046982	protein heterodimerization activity

Biological Process

GO:0001833	inner cell mass cell proliferation
GO:0006351	transcription, DNA-templated
GO:0030154	cell differentiation
GO:0045598	regulation of fat cell differentiation
GO:0045893	positive regulation of transcription, DNA-templated
GO:0051457	maintenance of protein location in nucleus