Version 5.4
Mus musculus Gene: Taf8
Summary
InnateDB Gene IDBG-189216.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Taf8
Gene Name TAF8 RNA polymerase II, TATA box binding protein (TBP)-associated factorq
Synonyms AW260255; Tbn
Species Mus musculus
Ensembl Gene ENSMUSG00000023980
Encoded Proteins
IDBP-189218
TAF8 RNA polymerase II, TATA box binding protein (TBP)-associated factorq
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000137413:
This gene encodes one of several TATA-binding protein (TBP)-associated factors (TAFs), which are integral subunits of the general transcription factor complex TFIID. TFIID recognizes the core promoter of many genes and nucleates the assembly of a transcription preinitiation complex containing RNA polymerase II and other initiation factors. The protein encoded by this gene contains an H4-like histone fold domain, and interacts with several subunits of TFIID including TBP and the histone-fold protein TAF10. Alternatively spliced transcript variants have been described, but their biological validity has not been determined. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 17:47488050-47502287
Strand Reverse strand
Band C
Transcripts
ENSMUST00000067103 ENSMUSP00000063201
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 14 interaction(s) predicted by orthology.
Predicted by orthology
Total 14 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0046982 protein heterodimerization activity
Biological Process
GO:0001833 inner cell mass cell proliferation
GO:0006351 transcription, DNA-templated
GO:0030154 cell differentiation
GO:0045598 regulation of fat cell differentiation
GO:0045893 positive regulation of transcription, DNA-templated
GO:0051457 maintenance of protein location in nucleus
Cellular Component
GO:0005634 nucleus
GO:0005669 transcription factor TFIID complex
GO:0048471 perinuclear region of cytoplasm
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000137413
View Gene Order
ENSBTAG00000011339
Not yet available
Pathways
NETPATH
REACTOME
KEGG
mmu03022
Basal transcription factors pathway
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
KEGG
hsa03022
Basal transcription factors pathway
INOH
PID NCI
Cross-References
SwissProt Q9EQH4
TrEMBL
UniProt Splice Variant
Entrez Gene 63856
UniGene Mm.275901
RefSeq NM_022015
OMIM
CCDS CCDS37642
HPRD
IMGT
MGI ID MGI:1926879
MGI Symbol Taf8
EMBL AF222802 AK045108 AK049949 AK076486 AK086656 AK162110 BC057895
GenPept AAG01682 AAH57895 BAC32225 BAC34001 BAC36363 BAC39712 BAE36731
RNA Seq Atlas 63856

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca