InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Rangrf

Summary

InnateDB Protein

IDBP-189444.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Rangrf

Protein Name

RAN guanine nucleotide release factor

Synonyms

2400006H24Rik; Mog1; Rangnrf;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000038485

InnateDB Gene

IDBG-189442 (Rangrf)

Protein Structure

UniProt Annotation

Function

May regulate the intracellular trafficking of RAN. In cardiac cells seems to regulate the cell surface localization of SCN5A. {ECO:0000269PubMed:10811801, ECO:0000269PubMed:11733047, ECO:0000269PubMed:18184654}.

Subcellular Localization

Nucleus. Cytoplasm. Note=Shuttles between the nucleus and cytoplasm.

Disease Associations

Tissue Specificity

Highgly abundant in cardiac cells. Expressed in testis during prepubertal development. {ECO:0000269PubMed:18184654}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	4 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005085	guanyl-nucleotide exchange factor activity
GO:0005087	Ran guanyl-nucleotide exchange factor activity
GO:0008536	Ran GTPase binding
GO:0017080	sodium channel regulator activity
GO:0044325	ion channel binding

Biological Process

GO:0003254	regulation of membrane depolarization
GO:0006913	nucleocytoplasmic transport
GO:0015031	protein transport
GO:0032316	regulation of Ran GTPase activity
GO:0043087	regulation of GTPase activity
GO:1902305	regulation of sodium ion transmembrane transport
GO:2000649	regulation of sodium ion transmembrane transporter activity