Version 5.4
Mus musculus Gene: Rangrf
Summary
InnateDB Gene IDBG-189442.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Rangrf
Gene Name RAN guanine nucleotide release factor
Synonyms 2400006H24Rik; Mog1; Rangnrf
Species Mus musculus
Ensembl Gene ENSMUSG00000032892
Encoded Proteins
IDBP-189444
RAN guanine nucleotide release factor
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000108961:
This gene encodes a protein that has been shown to function as a guanine nucleotide release factor in mouse and to regulate the expression and function of the Nav1.5 cardiac sodium channel in human. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 11:68972484-68975185
Strand Reverse strand
Band B3
Transcripts
ENSMUST00000038644 ENSMUSP00000038485
ENSMUST00000138362
ENSMUST00000132093
ENSMUST00000150017
ENSMUST00000143444
ENSMUST00000144271
ENSMUST00000156178
ENSMUST00000133099
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 4 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005085 guanyl-nucleotide exchange factor activity
GO:0005087 Ran guanyl-nucleotide exchange factor activity
GO:0008536 Ran GTPase binding
GO:0017080 sodium channel regulator activity
GO:0044325 ion channel binding
Biological Process
GO:0003254 regulation of membrane depolarization
GO:0006913 nucleocytoplasmic transport
GO:0015031 protein transport
GO:0032316 regulation of Ran GTPase activity
GO:0043087 regulation of GTPase activity
GO:1902305 regulation of sodium ion transmembrane transport
GO:2000649 regulation of sodium ion transmembrane transporter activity
Cellular Component
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0014704 intercalated disc
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000108961
View Gene Order
ENSBTAG00000018809
Not yet available
Cross-References
SwissProt Q9JIB0
TrEMBL
UniProt Splice Variant
Entrez Gene 57785
UniGene Mm.371612 Mm.397017
RefSeq NM_001285442 NM_001285443 NM_021329
OMIM
CCDS CCDS24875
HPRD
IMGT
MGI ID MGI:1889073
MGI Symbol Rangrf
EMBL AF243512 AK010288 AL603662 BC038470 BC087921
GenPept AAF91320 AAH38470 AAH87921 BAB26824 CAI25537
RNA Seq Atlas 57785

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca