InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Smug1

Summary

InnateDB Protein

IDBP-189459.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Smug1

Protein Name

single-strand selective monofunctional uracil DNA glycosylase

Synonyms

1200013B09Rik; A930006H09Rik; C85220;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000065835

InnateDB Gene

IDBG-189457 (Smug1)

Protein Structure

UniProt Annotation

Function

Responsible for recognizing base lesions in the genome and initiating base excision DNA repair. Acts as a monofunctional DNA glycosylase specific for uracil (U) residues in DNA and has a preference for single-stranded DNA substrates. The activity is greater against mismatches (U/G) than against matches (U/A). Excised uracil (U), 5-formyluracil (fU) and uracil derivatives bearing an oxidized group at C5 [5-hydroxyuracil (hoU) and 5- hydroxymethyluracil (hmU)] in ssDNA and dsDNA but not analogous cytosine derivatives (5-hydroxycytosine and 5-formylcytosine) and other oxidized damage. The activity is damage specificity and salt concentration-dependent. The general order of the preference for ssDNA and dsDNA is the following: ssDNA > dsDNA (G pair) = dsDNA (A pair) at the low salt concentration. At the high concentration dsDNA (G pair) > dsDNA (A pair) > ssDNA (By similarity). {ECO:0000250}.

Subcellular Localization

Nucleus {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.

Predicted by orthology
Total	5 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000702	oxidized base lesion DNA N-glycosylase activity
GO:0000703	oxidized pyrimidine nucleobase lesion DNA N-glycosylase activity
GO:0003697	single-stranded DNA binding
GO:0004844	uracil DNA N-glycosylase activity
GO:0005515	protein binding
GO:0017065	single-strand selective uracil DNA N-glycosylase activity
GO:0019104	DNA N-glycosylase activity

Biological Process

GO:0000737	DNA catabolic process, endonucleolytic
GO:0006281	DNA repair
GO:0006284	base-excision repair

Cellular Component

GO:0005730

nucleolus

Protein Structure and Domains

PDB ID

MGI:1918976

InterPro

IPR005122 Uracil-DNA glycosylase-like

PFAM

PF03167

PRINTS

PIRSF

SMART

SM00986

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q6P5C5

PhosphoSite

PhosphoSite-Q6P5C5

TrEMBL

UniProt Splice Variant

Entrez Gene

71726

UniGene

RefSeq

NP_082161

MGI ID

MGI Symbol

Smug1

OMIM

CCDS

CCDS27898

HPRD

IMGT

EMBL

AK004735 BC050253 BC062960

GenPept

AAH50253 AAH62960 BAB23517