Version 5.4
| Mus musculus Protein: Pfas | |||||||||
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| Summary | |||||||||
| InnateDB Protein | IDBP-189474.6 | ||||||||
| Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||
| Gene Symbol | Pfas | ||||||||
| Protein Name | phosphoribosylformylglycinamidine synthase (FGAR amidotransferase) | ||||||||
| Synonyms | |||||||||
| Species | Mus musculus | ||||||||
| Ensembl Protein | ENSMUSP00000021282 | ||||||||
| InnateDB Gene | IDBG-189472 (Pfas) | ||||||||
| Protein Structure |
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| UniProt Annotation | |||||||||
| Function | Phosphoribosylformylglycinamidine synthase involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate (By similarity). {ECO:0000250}. | ||||||||
| Subcellular Localization | Cytoplasm {ECO:0000250}. | ||||||||
| Disease Associations | |||||||||
| Tissue Specificity | |||||||||
| Comments | |||||||||
| Interactions | |||||||||
| Number of Interactions |
This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 28 interaction(s) predicted by orthology.
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| Gene Ontology | |||||||||
Molecular Function |
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| Biological Process |
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| Cellular Component |
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| Protein Structure and Domains | |||||||||
| PDB ID | MGI:2684864 | ||||||||
| InterPro |
IPR000728
AIR synthase related protein, N-terminal domain IPR010073 Phosphoribosylformylglycinamidine synthase IPR010918 AIR synthase-related protein, C-terminal domain IPR016188 PurM, N-terminal-like IPR029062 Class I glutamine amidotransferase-like |
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| PFAM |
PF00586
PF02769 |
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| PRINTS | |||||||||
| PIRSF | |||||||||
| SMART | |||||||||
| TIGRFAMs | |||||||||
| Post-translational Modifications | |||||||||
| Modification | |||||||||
| Cross-References | |||||||||
| SwissProt | Q5SUR0 | ||||||||
| PhosphoSite | PhosphoSite-Q5SUR0 | ||||||||
| TrEMBL | Q14BH5 | ||||||||
| UniProt Splice Variant | |||||||||
| Entrez Gene | 237823 | ||||||||
| UniGene | Mm.475033 | ||||||||
| RefSeq | NP_001152991 | ||||||||
| MGI ID | |||||||||
| MGI Symbol | Pfas | ||||||||
| OMIM | |||||||||
| CCDS | CCDS48823 | ||||||||
| HPRD | |||||||||
| IMGT | |||||||||
| EMBL | AK172938 AL645902 BC114997 BC115876 | ||||||||
| GenPept | AAI14998 AAI15877 BAD32216 CAI24440 | ||||||||