Version 5.4
Mus musculus Gene: Pfas
Summary
InnateDB Gene IDBG-189472.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Pfas
Gene Name phosphoribosylformylglycinamidine synthase (FGAR amidotransferase)
Synonyms
Species Mus musculus
Ensembl Gene ENSMUSG00000020899
Encoded Proteins
IDBP-189474
phosphoribosylformylglycinamidine synthase (FGAR amidotransferase)
IDBP-538564
phosphoribosylformylglycinamidine synthase (FGAR amidotransferase)
IDBP-627267
phosphoribosylformylglycinamidine synthase (FGAR amidotransferase)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000178921:
Purines are necessary for many cellular processes, including DNA replication, transcription, and energy metabolism. Ten enzymatic steps are required to synthesize inosine monophosphate (IMP) in the de novo pathway of purine biosynthesis. The enzyme encoded by this gene catalyzes the fourth step of IMP biosynthesis. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 11:68985697-69008460
Strand Reverse strand
Band B3
Transcripts
ENSMUST00000021282 ENSMUSP00000021282
ENSMUST00000146490
ENSMUST00000152964 ENSMUSP00000121808
ENSMUST00000149703 ENSMUSP00000133984
ENSMUST00000172915
ENSMUST00000173410
ENSMUST00000172987
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 28 interaction(s) predicted by orthology.
Predicted by orthology
Total 28 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003824 catalytic activity
GO:0004642 phosphoribosylformylglycinamidine synthase activity
GO:0005524 ATP binding
Biological Process
GO:0006189 'de novo' IMP biosynthetic process
GO:0006541 glutamine metabolic process
GO:0009156 ribonucleoside monophosphate biosynthetic process
GO:0042493 response to drug
Cellular Component
GO:0005737 cytoplasm
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000178921
View Gene Order
ENSBTAG00000031509
Not yet available
Pathways
NETPATH
REACTOME
REACT_263730
Purine metabolism pathway
REACT_188937
Metabolism pathway
REACT_263184
Purine ribonucleoside monophosphate biosynthesis pathway
REACT_245662
Metabolism of nucleotides pathway
KEGG
mmu00230
Purine metabolism pathway
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_1776
Purine ribonucleoside monophosphate biosynthesis pathway
REACT_1698
Metabolism of nucleotides pathway
REACT_522
Purine metabolism pathway
REACT_111217
Metabolism pathway
KEGG
hsa00230
Purine metabolism pathway
INOH
INOH website
Purine nucleotides nucleosides metabolism pathway
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Mm.410320 Mm.475033
RefSeq NM_001159519
OMIM
CCDS CCDS48823
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca