Version 5.4
| Mus musculus Protein: Ankle2 | |||||||||
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| Summary | |||||||||
| InnateDB Protein | IDBP-189507.6 | ||||||||
| Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||
| Gene Symbol | Ankle2 | ||||||||
| Protein Name | ankyrin repeat and LEM domain containing 2 | ||||||||
| Synonyms | 1110001J12Rik; AI661024; D5Ertd585e; | ||||||||
| Species | Mus musculus | ||||||||
| Ensembl Protein | ENSMUSP00000031474 | ||||||||
| InnateDB Gene | IDBG-189505 (Ankle2) | ||||||||
| Protein Structure |
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| UniProt Annotation | |||||||||
| Function | Involved in mitotic nuclear envelope reassembly by promoting dephosphorylation of BAF/BANF1 during mitotic exit. Coordinates the control of BAF/BANF1 dephosphorylation by inhibiting VRK1 kinase and promoting dephosphorylation of BAF/BANF1 by protein phosphatase 2A (PP2A), thereby facilitating nuclear envelope assembly. It is unclear whether it acts as a real PP2A regulatory subunit or whether it is involved in recruitment of the PP2A complex (By similarity). {ECO:0000250}. | ||||||||
| Subcellular Localization | Endoplasmic reticulum membrane {ECO:0000250}; Single-pass type III membrane protein {ECO:0000250}. | ||||||||
| Disease Associations | |||||||||
| Tissue Specificity | |||||||||
| Comments | |||||||||
| Interactions | |||||||||
| Number of Interactions |
This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 8 interaction(s) predicted by orthology.
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| Gene Ontology | |||||||||
Molecular Function |
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| Biological Process |
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| Cellular Component |
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| Protein Structure and Domains | |||||||||
| PDB ID | MGI:1261856 | ||||||||
| InterPro |
IPR003887
LEM domain IPR009027 Ribosomal protein L9/RNase H1, N-terminal IPR011015 LEM/LEM-like domain IPR020683 Ankyrin repeat-containing domain |
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| PFAM |
PF03020
PF11929 PF12796 |
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| PRINTS | |||||||||
| PIRSF | |||||||||
| SMART |
SM00540
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| TIGRFAMs | |||||||||
| Post-translational Modifications | |||||||||
| Modification | |||||||||
| Cross-References | |||||||||
| SwissProt | Q6P1H6 | ||||||||
| PhosphoSite | PhosphoSite-Q6P1H6 | ||||||||
| TrEMBL | |||||||||
| UniProt Splice Variant | |||||||||
| Entrez Gene | 71782 | ||||||||
| UniGene | Mm.410532 | ||||||||
| RefSeq | NP_082198 | ||||||||
| MGI ID | |||||||||
| MGI Symbol | Ankle2 | ||||||||
| OMIM | |||||||||
| CCDS | CCDS57372 | ||||||||
| HPRD | |||||||||
| IMGT | |||||||||
| EMBL | AK003234 AK043925 AK129192 AK132187 AK134966 AK142497 BC065071 | ||||||||
| GenPept | AAH65071 BAB22659 BAC31703 BAC98002 BAE21022 BAE22361 BAE25086 | ||||||||