InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Dus2l

Summary

InnateDB Protein

IDBP-189528.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Dus2l

Protein Name

dihydrouridine synthase 2-like (SMM1, S. cerevisiae)

Synonyms

2310016K04Rik; Dus2l;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000034375

InnateDB Gene

IDBG-189526 (Dus2l)

Protein Structure

UniProt Annotation

Function

Dihydrouridine synthase. Catalyzes the synthesis of dihydrouridine, a modified base found in the D-loop of most tRNAs (By similarity). Negatively regulates the activation of EIF2AK2/PKR (By similarity). {ECO:0000250}.

Subcellular Localization

Cytoplasm {ECO:0000250}. Endoplasmic reticulum {ECO:0000250}. Note=Mainly at the endoplasmic reticulum. {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.

Predicted by orthology
Total	3 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003725	double-stranded RNA binding
GO:0004860	protein kinase inhibitor activity
GO:0005515	protein binding
GO:0017150	tRNA dihydrouridine synthase activity
GO:0050660	flavin adenine dinucleotide binding

Biological Process

GO:0002943	tRNA dihydrouridine synthesis
GO:0006469	negative regulation of protein kinase activity
GO:0008033	tRNA processing
GO:0055114	oxidation-reduction process
GO:0060548	negative regulation of cell death