Version 5.4
Mus musculus Gene: Dus2l
Summary
InnateDB Gene IDBG-189526.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Dus2l
Gene Name dihydrouridine synthase 2-like (SMM1, S. cerevisiae)
Synonyms 2310016K04Rik; Dus2l
Species Mus musculus
Ensembl Gene ENSMUSG00000031901
Encoded Proteins
IDBP-189528
dihydrouridine synthase 2-like (SMM1, S. cerevisiae)
IDBP-400528
dihydrouridine synthase 2-like (SMM1, S. cerevisiae)
IDBP-538463
dihydrouridine synthase 2-like (SMM1, S. cerevisiae)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000167264:
This gene encodes a cytoplasmic protein that catalyzes the conversion of uridine residues to dihydrouridine in the D-loop of tRNA. The resulting modified bases confer enhanced regional flexibility to tRNA. The encoded protein may increase the rate of translation by inhibiting an interferon-induced protein kinase. This gene has been implicated in pulmonary carcinogenesis. Alternatively spliced transcript variants have been described for this gene. [provided by RefSeq, Nov 2012]
Gene Information
Type Protein coding
Genomic Location Chromosome 8:105991337-106053840
Strand Forward strand
Band D3
Transcripts
ENSMUST00000034375 ENSMUSP00000034375
ENSMUST00000119736 ENSMUSP00000113781
ENSMUST00000142898 ENSMUSP00000120375
ENSMUST00000141374
ENSMUST00000138524
ENSMUST00000144904
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.
Predicted by orthology
Total 3 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003725 double-stranded RNA binding
GO:0004860 protein kinase inhibitor activity
GO:0005515 protein binding
GO:0017150 tRNA dihydrouridine synthase activity
GO:0050660 flavin adenine dinucleotide binding
Biological Process
GO:0002943 tRNA dihydrouridine synthesis
GO:0006469 negative regulation of protein kinase activity
GO:0008033 tRNA processing
GO:0055114 oxidation-reduction process
GO:0060548 negative regulation of cell death
Cellular Component
GO:0005737 cytoplasm
GO:0005739 mitochondrion
GO:0005783 endoplasmic reticulum
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000167264
View Gene Order
ENSBTAG00000014644
Not yet available
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Mm.287500
RefSeq NM_025518 XM_006531278 XM_006531280
OMIM
CCDS CCDS22627
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca