Version 5.4
Mus musculus Protein: Me1
Summary
InnateDB Protein IDBP-189595.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Me1
Protein Name malic enzyme 1, NADP(+)-dependent, cytosolic
Synonyms D9Ertd267e; Mdh-1; Mod-1; Mod1;
Species Mus musculus
Ensembl Protein ENSMUSP00000034989
InnateDB Gene IDBG-189593 (Me1)
Protein Structure
UniProt Annotation
Function
Subcellular Localization Cytoplasm.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 7 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 7 [view]
Protein-Protein 7 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004470 malic enzyme activity
GO:0004471 malate dehydrogenase (decarboxylating) (NAD+) activity
GO:0004473 malate dehydrogenase (oxaloacetate-decarboxylating) (NADP+) activity
GO:0005515 protein binding
GO:0008948 oxaloacetate decarboxylase activity
GO:0030145 manganese ion binding
GO:0051287 NAD binding
Biological Process
GO:0006108 malate metabolic process
GO:0009725 response to hormone
GO:0051262 protein tetramerization
GO:0055114 oxidation-reduction process
Cellular Component
GO:0005739 mitochondrion
GO:0005829 cytosol
Protein Structure and Domains
PDB ID MGI:97043
InterPro IPR001891 Malic oxidoreductase
IPR012301 Malic enzyme, N-terminal domain
IPR012302 Malic enzyme, NAD-binding
PFAM PF00390
PF03949
PRINTS PR00072
PIRSF PIRSF000106
SMART SM00919
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt P06801
PhosphoSite PhosphoSite-P06801
TrEMBL
UniProt Splice Variant
Entrez Gene 17436
UniGene Mm.426355
RefSeq NP_032641
MGI ID
MGI Symbol Me1
OMIM
CCDS CCDS23383
HPRD
IMGT
EMBL AK004980 AK077968 J02652 M26756
GenPept AAA39489 AAA39727 BAB23716 BAC37086

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca