InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Me1

Summary

InnateDB Gene

IDBG-189593.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Me1

Gene Name

malic enzyme 1, NADP(+)-dependent, cytosolic

Synonyms

D9Ertd267e; Mdh-1; Mod-1; Mod1

Species

Mus musculus

Ensembl Gene

ENSMUSG00000032418

Encoded Proteins

IDBP-189595

malic enzyme 1, NADP(+)-dependent, cytosolic

IDBP-788595

malic enzyme 1, NADP(+)-dependent, cytosolic

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000065833:
This gene encodes a cytosolic, NADP-dependent enzyme that generates NADPH for fatty acid biosynthesis. The activity of this enzyme, the reversible oxidative decarboxylation of malate, links the glycolytic and citric acid cycles. The regulation of expression for this gene is complex. Increased expression can result from elevated levels of thyroid hormones or by higher proportions of carbohydrates in the diet. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 9:86581371-86695953

Strand

Reverse strand

Band

E3.1

Transcripts

ENSMUST00000034989	ENSMUSP00000034989
ENSMUST00000185374	ENSMUSP00000140887
ENSMUST00000189968
ENSMUST00000189847

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 7 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	7 [view]
Protein-Protein	7 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004470	malic enzyme activity
GO:0004471	malate dehydrogenase (decarboxylating) (NAD+) activity
GO:0004473	malate dehydrogenase (oxaloacetate-decarboxylating) (NADP+) activity
GO:0005515	protein binding
GO:0008948	oxaloacetate decarboxylase activity
GO:0030145	manganese ion binding
GO:0051287	NAD binding