Version 5.4
Mus musculus Protein: Gja4
Summary
InnateDB Protein IDBP-189648.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Gja4
Protein Name gap junction protein, alpha 4
Synonyms AU020209; AW558810; Cnx37; Cx37; Gja-4;
Species Mus musculus
Ensembl Protein ENSMUSP00000062320
InnateDB Gene IDBG-189646 (Gja4)
Protein Structure
UniProt Annotation
Function One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.
Subcellular Localization Cell membrane; Multi-pass membrane protein. Cell junction, gap junction.
Disease Associations
Tissue Specificity Highly expressed in lung.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
Biological Process
GO:0001568 blood vessel development
GO:0003158 endothelium development
GO:0006816 calcium ion transport
GO:0007267 cell-cell signaling
GO:0048265 response to pain
Cellular Component
GO:0005921 gap junction
GO:0005922 connexon complex
GO:0016021 integral component of membrane
Protein Structure and Domains
PDB ID MGI:95715
InterPro IPR000500 Connexin
IPR002263 Gap junction alpha-4 protein (Cx37)
IPR013092 Connexin, N-terminal
IPR019570 Gap junction protein, cysteine-rich domain
PFAM PF00029
PF10582
PRINTS PR00206
PR01134
PIRSF
SMART SM00037
SM01089
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt P28235
PhosphoSite PhosphoSite-P28235
TrEMBL Q9JIN0
UniProt Splice Variant
Entrez Gene 14612
UniGene Mm.24615
RefSeq NP_032146
MGI ID
MGI Symbol Gja4
OMIM
CCDS CCDS18667
HPRD
IMGT
EMBL AF216831 AF216832 AK143024 CH466552 X57971
GenPept AAF91221 AAF91222 BAE25252 CAA41037 EDL30255

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca