Version 5.4
Mus musculus Protein: Gjb3
Summary
InnateDB Protein IDBP-189654.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Gjb3
Protein Name gap junction protein, beta 3
Synonyms Cnx31; Cx31; D4Wsu144e; Gjb-3;
Species Mus musculus
Ensembl Protein ENSMUSP00000046755
InnateDB Gene IDBG-189652 (Gjb3)
Protein Structure
UniProt Annotation
Function One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.
Subcellular Localization Cell membrane; Multi-pass membrane protein. Cell junction, gap junction.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.
Experimentally validated
Total 2 [view]
Protein-Protein 2 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 3 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
Biological Process
GO:0001701 in utero embryonic development
GO:0001890 placenta development
GO:0007154 cell communication
GO:0007605 sensory perception of sound
GO:0043588 skin development
Cellular Component
GO:0005737 cytoplasm
GO:0005911 cell-cell junction
GO:0005921 gap junction
GO:0005922 connexon complex
GO:0016021 integral component of membrane
Protein Structure and Domains
PDB ID MGI:95721
InterPro IPR000500 Connexin
IPR002269 Gap junction beta-3 protein (Cx31)
IPR013092 Connexin, N-terminal
IPR019570 Gap junction protein, cysteine-rich domain
PFAM PF00029
PF10582
PRINTS PR00206
PR01140
PIRSF
SMART SM00037
SM01089
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt P28231
PhosphoSite PhosphoSite-P28231
TrEMBL Q6TPJ0
UniProt Splice Variant
Entrez Gene 14620
UniGene Mm.90003
RefSeq NP_001153484
MGI ID
MGI Symbol Gjb3
OMIM
CCDS CCDS18668
HPRD
IMGT
EMBL AK083716 AY390400 BC024387 X63099
GenPept AAH24387 AAQ93033 BAC39002 CAA44813

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca