Version 5.4
Mus musculus Gene: Gjb3
Summary
InnateDB Gene IDBG-189652.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Gjb3
Gene Name gap junction protein, beta 3
Synonyms Cnx31; Cx31; D4Wsu144e; Gjb-3
Species Mus musculus
Ensembl Gene ENSMUSG00000042367
Encoded Proteins
IDBP-189654
gap junction protein, beta 3
IDBP-269489
gap junction protein, beta 3
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000188910:
This gene is a member of the connexin gene family. The encoded protein is a component of gap junctions, which are composed of arrays of intercellular channels that provide a route for the diffusion of low molecular weight materials from cell to cell. Mutations in this gene can cause non-syndromic deafness or erythrokeratodermia variabilis, a skin disorder. Alternative splicing results in multiple transcript variants encoding the same protein. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 4:127325235-127330844
Strand Reverse strand
Band D2.2
Transcripts
ENSMUST00000046532 ENSMUSP00000046755
ENSMUST00000106091 ENSMUSP00000101697
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.
Experimentally validated
Total 2 [view]
Protein-Protein 2 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 3 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
Biological Process
GO:0001701 in utero embryonic development
GO:0001890 placenta development
GO:0007154 cell communication
GO:0007605 sensory perception of sound
GO:0043588 skin development
Cellular Component
GO:0005737 cytoplasm
GO:0005911 cell-cell junction
GO:0005921 gap junction
GO:0005922 connexon complex
GO:0016021 integral component of membrane
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000188910
View Gene Order
ENSBTAG00000012584
Not yet available
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_9509
Gap junction assembly pathway
REACT_9411
Gap junction trafficking pathway
REACT_9480
Gap junction trafficking and regulation pathway
REACT_11123
Membrane Trafficking pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Mm.90003
RefSeq NM_001160012 NM_008126
OMIM
CCDS CCDS18668
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca