InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Prmt7

Summary

InnateDB Protein

IDBP-189813.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Prmt7

Protein Name

protein arginine N-methyltransferase 7

Synonyms

Species

Mus musculus

Ensembl Protein

ENSMUSP00000071521

InnateDB Gene

IDBG-189811 (Prmt7)

Protein Structure

UniProt Annotation

Function

Arginine methyltransferase that can both catalyze the formation of omega-N monomethylarginine (MMA) and symmetrical dimethylarginine (sDMA), with a preference for the formation of MMA. Specifically mediates the symmetrical dimethylation of arginine residues in the small nuclear ribonucleoproteins Sm D1 (SNRPD1) and Sm D3 (SNRPD3); such methylation being required for the assembly and biogenesis of snRNP core particles. Specifically mediates the symmetric dimethylation of histone H4 'Arg-3' to form H4R3me2s. Plays a role in gene imprinting by being recruited by CTCFL at the H19 imprinted control region (ICR) and methylating histone H4 to form H4R3me2s, possibly leading to recruit DNA methyltransferases at these sites. May also play a role in embryonic stem cell (ESC) pluripotency. Also able to mediate the arginine methylation of histone H2A and myelin basic protein (MBP) in vitro; the relevance of such results is however unclear in vivo (By similarity). {ECO:0000250}.

Subcellular Localization

Cytoplasm, cytosol {ECO:0000250}. Nucleus {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 8 interaction(s) predicted by orthology.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	8 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0008168	methyltransferase activity
GO:0008276	protein methyltransferase activity
GO:0008469	histone-arginine N-methyltransferase activity
GO:0008757	S-adenosylmethionine-dependent methyltransferase activity
GO:0016277	[myelin basic protein]-arginine N-methyltransferase activity
GO:0035241	protein-arginine omega-N monomethyltransferase activity
GO:0035242	protein-arginine omega-N asymmetric methyltransferase activity
GO:0035243	protein-arginine omega-N symmetric methyltransferase activity
GO:0043021	ribonucleoprotein complex binding
GO:0044020	histone methyltransferase activity (H4-R3 specific)

Biological Process

GO:0000387	spliceosomal snRNP assembly
GO:0006349	regulation of gene expression by genetic imprinting
GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0006479	protein methylation
GO:0016571	histone methylation
GO:0018216	peptidyl-arginine methylation
GO:0019918	peptidyl-arginine methylation, to symmetrical-dimethyl arginine
GO:0019919	peptidyl-arginine methylation, to asymmetrical-dimethyl arginine
GO:0030154	cell differentiation
GO:0034969	histone arginine methylation
GO:0043046	DNA methylation involved in gamete generation
GO:0043985	histone H4-R3 methylation

Cellular Component

GO:0005634	nucleus
GO:0005730	nucleolus
GO:0005737	cytoplasm
GO:0005829	cytosol
GO:0005886	plasma membrane

Protein Structure and Domains

PDB ID

MGI:2384879

InterPro

IPR010456 Ribosomal L11 methyltransferase, PrmA
IPR014644 Protein arginine N-methyltransferase PRMT7
IPR029063 S-adenosyl-L-methionine-dependent methyltransferase-like

PFAM

PF06325

PRINTS

PIRSF

PIRSF036946

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q922X9