Version 5.4
Mus musculus Protein: Smpd3
Summary
InnateDB Protein IDBP-189854.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Smpd3
Protein Name sphingomyelin phosphodiesterase 3, neutral
Synonyms 4631433G07Rik; AI427456; AW537966; fro; nSMase2;
Species Mus musculus
Ensembl Protein ENSMUSP00000069255
InnateDB Gene IDBG-189852 (Smpd3)
Protein Structure
UniProt Annotation
Function Catalyzes the hydrolysis of sphingomyelin to form ceramide and phosphocholine. Ceramide mediates numerous cellular functions, such as apoptosis and growth arrest, and is capable of regulating these 2 cellular events independently. Also hydrolyzes sphingosylphosphocholine. Regulates the cell cycle by acting as a growth suppressor in confluent cells. Acts as a regulator of postnatal development and participates in bone and dentin mineralization. Overexpression enhances cell death, suggesting that it may be involved in apoptosis control. {ECO:0000269PubMed:15051724, ECO:0000269PubMed:15764706, ECO:0000269PubMed:15929065, ECO:0000269PubMed:16025116}.
Subcellular Localization Golgi apparatus membrane; Lipid-anchor. Cell membrane {ECO:0000250}; Lipid-anchor {ECO:0000250}. Note=May localize to detergent-resistant subdomains of Golgi membranes of hypothalamic neurosecretory neurons.
Disease Associations
Tissue Specificity Predominantly expressed in brain (at protein level). {ECO:0000269PubMed:10823942}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 10 interaction(s) predicted by orthology.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 10 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004767 sphingomyelin phosphodiesterase activity
GO:0046872 metal ion binding
Biological Process
GO:0002244 hematopoietic progenitor cell differentiation
GO:0006684 sphingomyelin metabolic process
GO:0007049 cell cycle
GO:0007165 signal transduction
GO:0030072 peptide hormone secretion
Cellular Component
GO:0000137 Golgi cis cisterna
GO:0000139 Golgi membrane
GO:0005794 Golgi apparatus
GO:0005886 plasma membrane
Protein Structure and Domains
PDB ID MGI:1927578
InterPro IPR005135 Endonuclease/exonuclease/phosphatase
PFAM PF03372
PF14529
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9JJY3
PhosphoSite PhosphoSite-Q9JJY3
TrEMBL Q3US57
UniProt Splice Variant
Entrez Gene 58994
UniGene Mm.487528
RefSeq NP_067466
MGI ID
MGI Symbol Smpd3
OMIM
CCDS CCDS22634
HPRD
IMGT
EMBL AJ250461 AK019476 AK139226 AK140788 BC043077 BC046980
GenPept AAH43077 AAH46980 BAB31745 BAE23925 BAE24479 CAB92970

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca