InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: E2f7

Summary

InnateDB Protein

IDBP-189876.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

E2f7

Protein Name

E2F transcription factor 7

Synonyms

A630014C11Rik; D10Ertd739e;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000073453

InnateDB Gene

IDBG-189874 (E2f7)

Protein Structure

UniProt Annotation

Function

Atypical E2F transcription factor that participates in various processes such as angiogenesis, polyploidization of specialized cells and DNA damage response. Mainly acts as a transcription repressor that binds DNA independently of DP proteins and specifically recognizes the E2 recognition site 5'- TTTC[CG]CGC-3'. Directly represses transcription of classical E2F transcription factors such as E2F1. Acts as a regulator of S-phase by recognizing and binding the E2-related site 5'-TTCCCGCC-3' and mediating repression of G1/S-regulated genes. Plays a key role in polyploidization of cells in placenta and liver by regulating the endocycle, probably by repressing genes promoting cytokinesis and antagonizing action of classical E2F proteins (E2F1, E2F2 and/or E2F3). Required for placental development by promoting polyploidization of trophoblast giant cells. Also involved in DNA damage response: up-regulated by p53/TP53 following genotoxic stress and acts as a downstream effector of p53/TP53-dependent repression by mediating repression of indirect p53/TP53 target genes involved in DNA replication. Acts as a promoter of sprouting angiogenesis, possibly by acting as a transcription activator: associates with HIF1A, recognizes and binds the VEGFA promoter, which is different from canonical E2 recognition site, and activates expression of the VEGFA gene. Acts as a negative regulator of keratinocyte differentiation. {ECO:0000269PubMed:12893818, ECO:0000269PubMed:18194653, ECO:0000269PubMed:22180533, ECO:0000269PubMed:22516201, ECO:0000269PubMed:22802529, ECO:0000269PubMed:22903062, ECO:0000269PubMed:23064264, ECO:0000269PubMed:23064266}.

Subcellular Localization

Nucleus {ECO:0000269PubMed:12893818}.

Disease Associations

Tissue Specificity

Widely expressed with highest levels in skin and thymus and very low levels in brain, muscle and stomach. Expressed in trophoblast giant cells throughout placenta development (at protein level). {ECO:0000269PubMed:12893818, ECO:0000269PubMed:22516201, ECO:0000269PubMed:23064266}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	3 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000977	RNA polymerase II regulatory region sequence-specific DNA binding
GO:0001047	core promoter binding
GO:0001227	RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0003714	transcription corepressor activity
GO:0005515	protein binding
GO:0042802	identical protein binding

Biological Process

GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0001890	placenta development
GO:0002040	sprouting angiogenesis
GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0008285	negative regulation of cell proliferation
GO:0030330	DNA damage response, signal transduction by p53 class mediator
GO:0032466	negative regulation of cytokinesis
GO:0032877	positive regulation of DNA endoreduplication
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0060707	trophoblast giant cell differentiation
GO:0060718	chorionic trophoblast cell differentiation
GO:0070365	hepatocyte differentiation
GO:0071930	negative regulation of transcription involved in G1/S transition of mitotic cell cycle
GO:2000134	negative regulation of G1/S transition of mitotic cell cycle