Version 5.4
Mus musculus Gene: E2f7
Summary
InnateDB Gene IDBG-189874.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol E2f7
Gene Name E2F transcription factor 7
Synonyms A630014C11Rik; D10Ertd739e
Species Mus musculus
Ensembl Gene ENSMUSG00000020185
Encoded Proteins
IDBP-189876
E2F transcription factor 7
IDBP-626299
E2F transcription factor 7
IDBP-626307
E2F transcription factor 7
IDBP-626308
E2F transcription factor 7
IDBP-626311
E2F transcription factor 7
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000165891:
E2F transcription factors, such as E2F7, play an essential role in the regulation of cell cycle progression (Di Stefano et al., 2003 [PubMed 14633988]).[supplied by OMIM, May 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 10:110745439-110787384
Strand Forward strand
Band D1
Transcripts
ENSMUST00000073781 ENSMUSP00000073453
ENSMUST00000173294
ENSMUST00000174857 ENSMUSP00000133801
ENSMUST00000174810
ENSMUST00000173471 ENSMUSP00000133494
ENSMUST00000173634 ENSMUSP00000133813
ENSMUST00000172574
ENSMUST00000173948 ENSMUSP00000134039
ENSMUST00000174593
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 3 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0000977 RNA polymerase II regulatory region sequence-specific DNA binding
GO:0001047 core promoter binding
GO:0001227 RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription
GO:0003700 sequence-specific DNA binding transcription factor activity
GO:0003714 transcription corepressor activity
GO:0005515 protein binding
GO:0042802 identical protein binding
Biological Process
GO:0000122 negative regulation of transcription from RNA polymerase II promoter
GO:0001890 placenta development
GO:0002040 sprouting angiogenesis
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0008285 negative regulation of cell proliferation
GO:0030330 DNA damage response, signal transduction by p53 class mediator
GO:0032466 negative regulation of cytokinesis
GO:0032877 positive regulation of DNA endoreduplication
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
GO:0060707 trophoblast giant cell differentiation
GO:0060718 chorionic trophoblast cell differentiation
GO:0070365 hepatocyte differentiation
GO:0071930 negative regulation of transcription involved in G1/S transition of mitotic cell cycle
GO:2000134 negative regulation of G1/S transition of mitotic cell cycle
Cellular Component
GO:0005634 nucleus
GO:0005667 transcription factor complex
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000165891
View Gene Order
ENSBTAG00000016931
Not yet available
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
KEGG
INOH
PID NCI
e2f_pathway
E2F transcription factor network
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Mm.11747
RefSeq NM_178609 XM_006513882 XM_006513883
OMIM
CCDS CCDS36055
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca