Version 5.4
Mus musculus Protein: Treml1
Summary
InnateDB Protein IDBP-189904.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Treml1
Protein Name triggering receptor expressed on myeloid cells-like 1
Synonyms 5430401J17Rik; TLT-1;
Species Mus musculus
Ensembl Protein ENSMUSP00000024792
InnateDB Gene IDBG-189902 (Treml1)
Protein Structure
UniProt Annotation
Function Cell surface receptor that may play a role in the innate and adaptive immune response. {ECO:0000269PubMed:12393607}.
Subcellular Localization Cell membrane {ECO:0000269PubMed:15100151}; Single-pass type I membrane protein {ECO:0000269PubMed:15100151}. Cytoplasm {ECO:0000269PubMed:15100151}. Note=Sequestered in cytoplasmic vesicles in resting platelets. Transported to the cell surface after stimulation by thrombin. Soluble fragments can be released into the serum by proteolysis.
Disease Associations
Tissue Specificity Highly expressed in bone marrow leukocytes, splenic megakaryocytes and platelets. Detected in brain, liver and in peritoneal monocytes. {ECO:0000269PubMed:12393607, ECO:0000269PubMed:15100151}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004872 receptor activity
GO:0005515 protein binding
Biological Process
GO:0009968 negative regulation of signal transduction
GO:0019722 calcium-mediated signaling
GO:0030168 platelet activation
GO:0042060 wound healing
Cellular Component
GO:0005886 plasma membrane
GO:0009986 cell surface
GO:0016021 integral component of membrane
GO:0031091 platelet alpha granule
Protein Structure and Domains
PDB ID MGI:1918576
InterPro IPR003599 Immunoglobulin subtype
PFAM
PRINTS
PIRSF
SMART SM00409
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q8K558
PhosphoSite PhosphoSite-Q8K558
TrEMBL
UniProt Splice Variant
Entrez Gene 71326
UniGene Mm.90177
RefSeq NP_082039
MGI ID
MGI Symbol Treml1
OMIM
CCDS CCDS28866
HPRD
IMGT
EMBL AK017256 AY078502 AY286071 BC138399
GenPept AAI38400 AAL85488 AAP33393 BAB30655

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca