InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Cd9

Summary

InnateDB Protein

IDBP-189940.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Cd9

Protein Name

CD9 antigen

Synonyms

Tspan29;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000032492

InnateDB Gene

IDBG-189938 (Cd9)

Protein Structure

UniProt Annotation

Function

Involved in platelet activation and aggregation. Regulates paranodal junction formation. Involved in cell adhesion, cell motility and tumor metastasis. Required for sperm-egg fusion (By similarity). Acts as a receptor for PSG17. {ECO:0000250, ECO:0000269PubMed:10700183, ECO:0000269PubMed:11805154, ECO:0000269PubMed:14715942}.

Subcellular Localization

Membrane {ECO:0000269PubMed:11805154}; Multi-pass membrane protein {ECO:0000269PubMed:11805154}. Cell membrane {ECO:0000269PubMed:11805154}; Multi-pass membrane protein {ECO:0000269PubMed:11805154}.

Disease Associations

Tissue Specificity

Expressed predominantly in the peripheral nervous system. {ECO:0000269PubMed:14715942}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
They are also associated with 27 interaction(s) predicted by orthology.

Experimentally validated
Total	4 [view]
Protein-Protein	3 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	27 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005178	integrin binding
GO:0005515	protein binding

Biological Process

GO:0006928	cellular component movement
GO:0007155	cell adhesion
GO:0007342	fusion of sperm to egg plasma membrane
GO:0007420	brain development
GO:0008285	negative regulation of cell proliferation
GO:0009414	response to water deprivation
GO:0014003	oligodendrocyte development
GO:0030913	paranodal junction assembly

Cellular Component

GO:0005615	extracellular space
GO:0005886	plasma membrane
GO:0009897	external side of plasma membrane
GO:0009986	cell surface
GO:0016021	integral component of membrane
GO:0016324	apical plasma membrane
GO:0070062	extracellular vesicular exosome