InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Hes7

Summary

InnateDB Protein

IDBP-189974.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Hes7

Protein Name

hairy and enhancer of split 7 (Drosophila)

Synonyms

bHLHb37;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000024543

InnateDB Gene

IDBG-189972 (Hes7)

Protein Structure

UniProt Annotation

Function

Transcriptional repressor. Represses transcription from both N box- and E box-containing promoters. May with HES1, cooperatively regulate somite formation in the presomitic mesoderm (PSM). May function as a segmentation clock, which is essential for coordinated somite segmentation. {ECO:0000269PubMed:11260262, ECO:0000269PubMed:15170214, ECO:0000269PubMed:18775957}.

Subcellular Localization

Nucleus {ECO:0000305}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003677	DNA binding
GO:0008134	transcription factor binding
GO:0046983	protein dimerization activity

Biological Process

GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0001501	skeletal system development
GO:0001756	somitogenesis
GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0007219	Notch signaling pathway
GO:0014807	regulation of somitogenesis
GO:0036342	post-anal tail morphogenesis
GO:0045892	negative regulation of transcription, DNA-templated
GO:0048511	rhythmic process