Version 5.4
Mus musculus Gene: Hes7
Summary
InnateDB Gene IDBG-189972.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Hes7
Gene Name hairy and enhancer of split 7 (Drosophila)
Synonyms bHLHb37
Species Mus musculus
Ensembl Gene ENSMUSG00000023781
Encoded Proteins
IDBP-189974
hairy and enhancer of split 7 (Drosophila)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000179111:
This gene encodes a member of the hairy and enhancer of split family of bHLH transcription factors. The mouse ortholog of this gene is regulated by Notch signaling. The protein functions as a transcriptional repressor, and is implicated in correct patterning of the axial skeleton. A mutation in this gene has been shown to result in spondylocostal dysostosis. Multiple transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Sep 2009]
Gene Information
Type Protein coding
Genomic Location Chromosome 11:69120404-69124055
Strand Forward strand
Band B3
Transcripts
ENSMUST00000024543 ENSMUSP00000024543
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003677 DNA binding
GO:0008134 transcription factor binding
GO:0046983 protein dimerization activity
Biological Process
GO:0000122 negative regulation of transcription from RNA polymerase II promoter
GO:0001501 skeletal system development
GO:0001756 somitogenesis
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0007219 Notch signaling pathway
GO:0014807 regulation of somitogenesis
GO:0036342 post-anal tail morphogenesis
GO:0045892 negative regulation of transcription, DNA-templated
GO:0048511 rhythmic process
Cellular Component
GO:0005634 nucleus
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000179111
View Gene Order
ENSBTAG00000012436
Not yet available
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
KEGG
INOH
PID NCI
Cross-References
SwissProt Q8BKT2
TrEMBL
UniProt Splice Variant
Entrez Gene 84653
UniGene Mm.98505
RefSeq NM_033041 XM_006534556
OMIM
CCDS CCDS24883
HPRD
IMGT
MGI ID MGI:2135679
MGI Symbol Hes7
EMBL AB049065 AB050104 AK050791 AL645527 BC134378
GenPept AAI34379 BAB39526 BAB41134 BAC34412 CAI35247
RNA Seq Atlas 84653

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca