Mus musculus Protein: Aloxe3 | |||||||||||||||||||||||
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Summary | |||||||||||||||||||||||
InnateDB Protein | IDBP-189992.6 | ||||||||||||||||||||||
Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||||||||||||
Gene Symbol | Aloxe3 | ||||||||||||||||||||||
Protein Name | arachidonate lipoxygenase 3 | ||||||||||||||||||||||
Synonyms | e-LOX-3; eLOX-3; | ||||||||||||||||||||||
Species | Mus musculus | ||||||||||||||||||||||
Ensembl Protein | ENSMUSP00000021268 | ||||||||||||||||||||||
InnateDB Gene | IDBG-189990 (Aloxe3) | ||||||||||||||||||||||
Protein Structure |
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UniProt Annotation | |||||||||||||||||||||||
Function | Non-heme iron-containing lipoxygenase which is atypical in that it displays a prominent hydroperoxide isomerase activity and a reduced dioxygenase activity compared to other lipoxygenases. The hydroperoxide isomerase activity catalyzes the isomerization of hydroperoxides, derived from arachidonic and linoleic acid by ALOX12B, into hepoxilin-type epoxyalcohols. The dioxygenase activity requires a step of activation of the enzyme by molecular oxygen. In presence of oxygen, oxygenates polyunsaturated fatty acids, including arachidonic acid, to produce fatty acid hydroperoxides. In the skin, acts downstream of ALOX12B on the linoleate moiety of esterified omega-hydroxyacyl- sphingosine (EOS) ceramides to produce an epoxy-ketone derivative, a crucial step in the conjugation of omega-hydroxyceramide to membrane proteins. Therefore plays a crucial role in the synthesis of corneocytes lipid envelope and the establishment of the skin barrier to water loss. In parallel, it may have a signaling function in barrier formation through the production of hepoxilins metabolites. Plays also a role in adipocyte differentiation through hepoxilin A3 and hepoxilin B3 production which in turn activate PPARG. Through the production of hepoxilins in the spinal cord, it may regulate inflammatory tactile allodynia. {ECO:0000269PubMed:17045234, ECO:0000269PubMed:20530198, ECO:0000269PubMed:22832496}. | ||||||||||||||||||||||
Subcellular Localization | Cytoplasm {ECO:0000255PROSITE- ProRule:PRU00726}. | ||||||||||||||||||||||
Disease Associations | |||||||||||||||||||||||
Tissue Specificity | Skin specific. | ||||||||||||||||||||||
Comments | |||||||||||||||||||||||
Interactions | |||||||||||||||||||||||
Number of Interactions |
This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
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Gene Ontology | |||||||||||||||||||||||
Molecular Function |
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Biological Process |
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Cellular Component |
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Protein Structure and Domains | |||||||||||||||||||||||
PDB ID | MGI:1345140 | ||||||||||||||||||||||
InterPro |
IPR001024
PLAT/LH2 domain IPR001885 Lipoxygenase, mammalian IPR008976 Lipase/lipooxygenase, PLAT/LH2 IPR013819 Lipoxygenase, C-terminal |
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PFAM |
PF01477
PF00305 |
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PRINTS |
PR00467
PR00087 |
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PIRSF | |||||||||||||||||||||||
SMART |
SM00308
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TIGRFAMs | |||||||||||||||||||||||
Post-translational Modifications | |||||||||||||||||||||||
Modification | |||||||||||||||||||||||
Cross-References | |||||||||||||||||||||||
SwissProt | Q9WV07 | ||||||||||||||||||||||
PhosphoSite | PhosphoSite-Q9WV07 | ||||||||||||||||||||||
TrEMBL | |||||||||||||||||||||||
UniProt Splice Variant | |||||||||||||||||||||||
Entrez Gene | 23801 | ||||||||||||||||||||||
UniGene | Mm.41989 | ||||||||||||||||||||||
RefSeq | NP_035916 | ||||||||||||||||||||||
MGI ID | |||||||||||||||||||||||
MGI Symbol | Aloxe3 | ||||||||||||||||||||||
OMIM | |||||||||||||||||||||||
CCDS | CCDS24884 | ||||||||||||||||||||||
HPRD | |||||||||||||||||||||||
IMGT | |||||||||||||||||||||||
EMBL | AL645527 CH466601 Y14695 | ||||||||||||||||||||||
GenPept | CAB46101 CAI35248 EDL10481 | ||||||||||||||||||||||