Version 5.4
Mus musculus Gene: Aloxe3
Summary
InnateDB Gene IDBG-189990.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Aloxe3
Gene Name arachidonate lipoxygenase 3
Synonyms e-LOX-3; eLOX-3
Species Mus musculus
Ensembl Gene ENSMUSG00000020892
Encoded Proteins
IDBP-189992
arachidonate lipoxygenase 3
IDBP-716718
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000179148:
This gene is a member of the lipoxygenase family, which are catabolized by arachidonic acid-derived compounds. The encoded enzyme is a hydroperoxide isomerase that synthesizes a unique type of epoxy alcohol (8R-hydroxy-11R,12R-epoxyeicosa-5Z,9E,14Z-trienoic acid) from 12R-hydroperoxyeicosatetraenoic acid (12R-HPETE). This epoxy alcohol can activate the the nuclear receptor peroxisome proliferator-activated receptor alpha (PPARalpha), which is implicated in epidermal differentiation. Loss of function of the enzyme encoded by this gene results in ichthyosis, implicating the function of this gene in the differentiation of human skin. This gene is part of a cluster of lipoxygenase genes on 17p13.1. Mutations in this gene result in nonbullous congenital ichthyosiform erythroderma (NCIE). Multiple transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Sep 2009]
Gene Information
Type Protein coding
Genomic Location Chromosome 11:69125896-69149115
Strand Forward strand
Band B3
Transcripts
ENSMUST00000021268 ENSMUSP00000021268
ENSMUST00000156874
ENSMUST00000155324
ENSMUST00000139257
ENSMUST00000176087
ENSMUST00000175661 ENSMUSP00000134814
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003824 catalytic activity
GO:0005506 iron ion binding
GO:0005515 protein binding
GO:0016702 oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen
GO:0046872 metal ion binding
GO:0051120 hepoxilin A3 synthase activity
Biological Process
GO:0006665 sphingolipid metabolic process
GO:0019233 sensory perception of pain
GO:0019369 arachidonic acid metabolic process
GO:0019372 lipoxygenase pathway
GO:0035357 peroxisome proliferator activated receptor signaling pathway
GO:0043651 linoleic acid metabolic process
GO:0045444 fat cell differentiation
GO:0046513 ceramide biosynthetic process
GO:0051122 hepoxilin biosynthetic process
GO:0055114 oxidation-reduction process
GO:0061436 establishment of skin barrier
Cellular Component
GO:0005737 cytoplasm
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000179148
View Gene Order
ENSBTAG00000012478
Not yet available
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Mm.41989
RefSeq NM_011786 XM_006533257
OMIM
CCDS CCDS24884
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca