InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Nt5e

Summary

InnateDB Protein

IDBP-190007.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Nt5e

Protein Name

5' nucleotidase, ecto

Synonyms

2210401F01Rik; AI447961; CD73; eNT; NT; Nt5;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000034992

InnateDB Gene

IDBG-190005 (Nt5e)

Protein Structure

UniProt Annotation

Function

Hydrolyzes extracellular nucleotides into membrane permeable nucleosides.

Subcellular Localization

Cell membrane {ECO:0000250}; Lipid-anchor, GPI-anchor {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
They are also associated with 8 interaction(s) predicted by orthology.

Experimentally validated
Total	4 [view]
Protein-Protein	4 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	8 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000166	nucleotide binding
GO:0008253	5'-nucleotidase activity
GO:0016787	hydrolase activity
GO:0046872	metal ion binding

Biological Process

GO:0006196	AMP catabolic process
GO:0009166	nucleotide catabolic process
GO:0016311	dephosphorylation
GO:0046086	adenosine biosynthetic process
GO:0050728	negative regulation of inflammatory response

Cellular Component

GO:0005737	cytoplasm
GO:0005886	plasma membrane
GO:0016020	membrane
GO:0031225	anchored component of membrane
GO:0070062	extracellular vesicular exosome

Protein Structure and Domains

PDB ID

MGI:99782

InterPro

IPR004843 Calcineurin-like phosphoesterase domain, apaH type
IPR006179 5\'-Nucleotidase/apyrase
IPR008334 5\'-Nucleotidase, C-terminal
IPR029052 Metallo-dependent phosphatase-like

PFAM

PF00149
PF02872

PRINTS

PR01607

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q61503