InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Nt5e

Summary

InnateDB Gene

IDBG-190005.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Nt5e

Gene Name

5' nucleotidase, ecto

Synonyms

2210401F01Rik; AI447961; CD73; eNT; NT; Nt5

Species

Mus musculus

Ensembl Gene

ENSMUSG00000032420

Encoded Proteins

IDBP-190007

5' nucleotidase, ecto

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000135318:
The protein encoded by this gene is a plasma membrane protein that catalyzes the conversion of extracellular nucleotides to membrane-permeable nucleosides. The encoded protein is used as a determinant of lymphocyte differentiation. Defects in this gene can lead to the calcification of joints and arteries. Two transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Mar 2011]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 9:88327197-88372092

Strand

Forward strand

Band

E3.1

Transcripts

ENSMUST00000034992	ENSMUSP00000034992
ENSMUST00000186789
ENSMUST00000187166

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
They are also associated with 8 interaction(s) predicted by orthology.

Experimentally validated
Total	4 [view]
Protein-Protein	4 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	8 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000166	nucleotide binding
GO:0008253	5'-nucleotidase activity
GO:0016787	hydrolase activity
GO:0046872	metal ion binding

Biological Process

GO:0006196	AMP catabolic process
GO:0009166	nucleotide catabolic process
GO:0016311	dephosphorylation
GO:0046086	adenosine biosynthetic process
GO:0050728	negative regulation of inflammatory response