InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Gucy2e

Summary

InnateDB Protein

IDBP-190205.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Gucy2e

Protein Name

guanylate cyclase 2e

Synonyms

GC-E; GC1; ROS-GC1;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000021259

InnateDB Gene

IDBG-190203 (Gucy2e)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Membrane; Single-pass type I membrane protein.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004383	guanylate cyclase activity
GO:0004672	protein kinase activity
GO:0004713	protein tyrosine kinase activity
GO:0005524	ATP binding
GO:0005525	GTP binding
GO:0016772	transferase activity, transferring phosphorus-containing groups
GO:0016849	phosphorus-oxygen lyase activity

Biological Process

GO:0006182	cGMP biosynthetic process
GO:0006468	protein phosphorylation
GO:0007601	visual perception
GO:0009190	cyclic nucleotide biosynthetic process
GO:0035556	intracellular signal transduction

Cellular Component

GO:0016021

integral component of membrane

Protein Structure and Domains

PDB ID

MGI:105123

InterPro

IPR000719 Protein kinase domain
IPR001054 Adenylyl cyclase class-3/4/guanylyl cyclase
IPR001245 Serine-threonine/tyrosine-protein kinase catalytic domain
IPR001828 Extracellular ligand-binding receptor
IPR002290 Serine/threonine- /dual specificity protein kinase, catalytic domain
IPR011009 Protein kinase-like domain
IPR011645 Haem NO binding associated
IPR020635 Tyrosine-protein kinase, catalytic domain
IPR028082 Periplasmic binding protein-like I

PFAM

PF00069
PF00211
PF07714
PF01094
PF07701

PRINTS

PR00109

PIRSF

SMART

SM00044
SM00220
SM00219

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt