InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Kcna1

Summary

InnateDB Protein

IDBP-190250.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Kcna1

Protein Name

potassium voltage-gated channel, shaker-related subfamily, member 1

Synonyms

AI840627; Kca1-1; Kv1.1; MBK1; mceph; Mk-1; Shak;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000055225

InnateDB Gene

IDBG-190248 (Kcna1)

Protein Structure

UniProt Annotation

Function

Mediates the voltage-dependent potassium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a potassium-selective channel through which potassium ions may pass in accordance with their electrochemical gradient.

Subcellular Localization

Membrane; Multi-pass membrane protein.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 7 interaction(s) predicted by orthology.

Experimentally validated
Total	3 [view]
Protein-Protein	3 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	7 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005216	ion channel activity
GO:0005251	delayed rectifier potassium channel activity
GO:0005515	protein binding

Biological Process

GO:0006811	ion transport
GO:0034765	regulation of ion transmembrane transport
GO:0051260	protein homooligomerization
GO:0055085	transmembrane transport
GO:0071805	potassium ion transmembrane transport

Cellular Component

GO:0008076	voltage-gated potassium channel complex
GO:0016020	membrane
GO:0016324	apical plasma membrane
GO:0030425	dendrite
GO:0043025	neuronal cell body
GO:0044224	juxtaparanode region of axon

Protein Structure and Domains

PDB ID

MGI:96654

InterPro

IPR000210 BTB/POZ-like
IPR003091 Potassium channel
IPR003131 Potassium channel tetramerisation-type BTB domain
IPR003968 Potassium channel, voltage dependent, Kv
IPR003972 Potassium channel, voltage dependent, Kv1
IPR004048 Potassium channel, voltage dependent, Kv1.1
IPR005821 Ion transport domain
IPR011333 BTB/POZ fold
IPR013099 Two pore domain potassium channel domain

PFAM

PF02214
PF00520
PF07885

PRINTS

PR00169
PR01491
PR01496
PR01508

PIRSF

SMART

SM00225

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt