InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Kcna1

Summary

InnateDB Gene

IDBG-190248.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Kcna1

Gene Name

potassium voltage-gated channel, shaker-related subfamily, member 1

Synonyms

AI840627; Kca1-1; Kv1.1; MBK1; mceph; Mk-1; Shak

Species

Mus musculus

Ensembl Gene

ENSMUSG00000047976

Encoded Proteins

IDBP-190250

potassium voltage-gated channel, shaker-related subfamily, member 1

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000111262:
This gene encodes a voltage-gated delayed potassium channel that is phylogenetically related to the Drosophila Shaker channel. The encoded protein has six putative transmembrane segments (S1-S6), and the loop between S5 and S6 forms the pore and contains the conserved selectivity filter motif (GYGD). The functional channel is a homotetramer. The N-terminus of the channel is associated with beta subunits that can modify the inactivation properties of the channel as well as affect expression levels. The C-terminus of the channel is complexed to a PDZ domain protein that is responsible for channel targeting. Mutations in this gene have been associated with myokymia with periodic ataxia (AEMK). [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 6:126636463-126645801

Strand

Reverse strand

Band

Transcripts

ENSMUST00000055168

ENSMUSP00000055225

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 7 interaction(s) predicted by orthology.

Experimentally validated
Total	3 [view]
Protein-Protein	3 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	7 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005216	ion channel activity
GO:0005251	delayed rectifier potassium channel activity
GO:0005515	protein binding

Biological Process

GO:0006811	ion transport
GO:0034765	regulation of ion transmembrane transport
GO:0051260	protein homooligomerization
GO:0055085	transmembrane transport
GO:0071805	potassium ion transmembrane transport

Cellular Component

GO:0008076	voltage-gated potassium channel complex
GO:0016020	membrane
GO:0016324	apical plasma membrane
GO:0030425	dendrite
GO:0043025	neuronal cell body
GO:0044224	juxtaparanode region of axon

Orthologs

Species

Homo sapiens

Bos taurus

Gene ID

Gene Order

ENSG00000111262

View Gene Order

ENSBTAG00000016646

Not yet available

Pathways

NETPATH

REACTOME

REACT_202800

Potassium Channels pathway

REACT_259290

Neuronal System pathway

REACT_199077

Voltage gated Potassium channels pathway

KEGG

INOH

PID NCI

Pathway Predictions based on Human Orthology Data

NETPATH

REACTOME

REACT_75770

Voltage gated Potassium channels pathway

REACT_13685

Neuronal System pathway

REACT_75908

Potassium Channels pathway

KEGG

INOH

PID NCI

Cross-References

SwissProt

P16388

TrEMBL

Q3TZ64

UniProt Splice Variant

Entrez Gene

16485

UniGene

Mm.40424 Mm.408702 Mm.422165 Mm.472362

RefSeq

NM_010595

OMIM

CCDS

CCDS20555

HPRD

IMGT

MGI ID

MGI:96654

MGI Symbol

Kcna1

EMBL

AK158065 M30439 Y00305

GenPept

AAA39711 BAE34346 CAA68408

RNA Seq Atlas

16485