InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Ak2

Summary

InnateDB Protein

IDBP-190272.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Ak2

Protein Name

adenylate kinase 2

Synonyms

Ak-2; D4Ertd220e;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000099664

InnateDB Gene

IDBG-190270 (Ak2)

Protein Structure

UniProt Annotation

Function

Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism. Adenylate kinase activity is critical for regulation of the phosphate utilization and the AMP de novo biosynthesis pathways. Plays a key role in hematopoiesis. {ECO:0000255HAMAP- Rule:MF_03168}.

Subcellular Localization

Mitochondrion intermembrane space {ECO:0000255HAMAP-Rule:MF_03168}.

Disease Associations

Tissue Specificity

Present in the inner ear. Not detected in the vestibule at any developmental stage. Present at high level in the cochlea uniquely in the stria vascularis at postnatal day 7 but not at birth. Present within the lumen of the stria vascularis capillaries. Not detected in the capillaries or vessels of the adjacent connective tissue (at protein level). {ECO:0000269PubMed:19043416}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 12 experimentally validated interaction(s) in this database.
They are also associated with 26 interaction(s) predicted by orthology.

Experimentally validated
Total	12 [view]
Protein-Protein	11 [view]
Protein-DNA	0
Protein-RNA	1 [view]
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	26 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004017	adenylate kinase activity
GO:0005524	ATP binding
GO:0016776	phosphotransferase activity, phosphate group as acceptor

Biological Process

GO:0001889	liver development
GO:0006119	oxidative phosphorylation
GO:0006172	ADP biosynthetic process
GO:0007420	brain development
GO:0046033	AMP metabolic process
GO:0046060	dATP metabolic process
GO:0046939	nucleotide phosphorylation
GO:0097066	response to thyroid hormone

Cellular Component

GO:0005739	mitochondrion
GO:0005743	mitochondrial inner membrane
GO:0005758	mitochondrial intermembrane space
GO:0005829	cytosol
GO:0036126	sperm flagellum
GO:0097226	sperm mitochondrial sheath

Protein Structure and Domains

PDB ID

MGI:87978

InterPro

IPR000850 Adenylate kinase/UMP-CMP kinase
IPR006259 Adenylate kinase subfamily
IPR007862 Adenylate kinase, active site lid domain
IPR027417 P-loop containing nucleoside triphosphate hydrolase

PFAM

PF05191

PRINTS

PR00094

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q9WTP6