InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Ak2

Summary

InnateDB Gene

IDBG-190270.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Ak2

Gene Name

adenylate kinase 2

Synonyms

Ak-2; D4Ertd220e

Species

Mus musculus

Ensembl Gene

ENSMUSG00000028792

Encoded Proteins

IDBP-190272

adenylate kinase 2

IDBP-190274

adenylate kinase 2

IDBP-536003

adenylate kinase 2

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000004455:
Adenylate kinases are involved in regulating the adenine nucleotide composition within a cell by catalyzing the reversible transfer of phosphate groups among adenine nucleotides. Three isozymes of adenylate kinase, namely 1, 2, and 3, have been identified in vertebrates; this gene encodes isozyme 2. Expression of these isozymes is tissue-specific and developmentally regulated. Isozyme 2 is localized in the mitochondrial intermembrane space and may play a role in apoptosis. Mutations in this gene are the cause of reticular dysgenesis. Alternate splicing results in multiple transcript variants. Pseudogenes of this gene are found on chromosomes 1 and 2.[provided by RefSeq, Nov 2010]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 4:128991958-129011529

Strand

Forward strand

Band

D2.2

Transcripts

ENSMUST00000102604	ENSMUSP00000099664
ENSMUST00000030583	ENSMUSP00000030583
ENSMUST00000141982
ENSMUST00000152762	ENSMUSP00000122284

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 12 experimentally validated interaction(s) in this database.
They are also associated with 26 interaction(s) predicted by orthology.

Experimentally validated
Total	12 [view]
Protein-Protein	11 [view]
Protein-DNA	0
Protein-RNA	1 [view]
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	26 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004017	adenylate kinase activity
GO:0005524	ATP binding
GO:0016776	phosphotransferase activity, phosphate group as acceptor
GO:0019205	nucleobase-containing compound kinase activity

Biological Process

GO:0001889	liver development
GO:0006119	oxidative phosphorylation
GO:0006139	nucleobase-containing compound metabolic process
GO:0006172	ADP biosynthetic process
GO:0007420	brain development
GO:0016310	phosphorylation
GO:0046033	AMP metabolic process
GO:0046034	ATP metabolic process
GO:0046060	dATP metabolic process
GO:0046939	nucleotide phosphorylation
GO:0097066	response to thyroid hormone

Cellular Component

GO:0005739	mitochondrion
GO:0005743	mitochondrial inner membrane
GO:0005758	mitochondrial intermembrane space
GO:0005829	cytosol
GO:0036126	sperm flagellum
GO:0070062	extracellular vesicular exosome
GO:0097226	sperm mitochondrial sheath