InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Pfkfb2

Summary

InnateDB Protein

IDBP-190315.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Pfkfb2

Protein Name

6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 2

Synonyms

4930568D07Rik;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000066426

InnateDB Gene

IDBG-190313 (Pfkfb2)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 7 interaction(s) predicted by orthology.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	7 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003873	6-phosphofructo-2-kinase activity
GO:0004331	fructose-2,6-bisphosphate 2-phosphatase activity
GO:0005524	ATP binding
GO:0019901	protein kinase binding

Biological Process

GO:0006000	fructose metabolic process
GO:0006003	fructose 2,6-bisphosphate metabolic process
GO:0006007	glucose catabolic process
GO:0006089	lactate metabolic process
GO:0006090	pyruvate metabolic process
GO:0006096	glycolytic process
GO:0009749	response to glucose
GO:0016311	dephosphorylation
GO:0032024	positive regulation of insulin secretion
GO:0033133	positive regulation of glucokinase activity
GO:0046835	carbohydrate phosphorylation

Cellular Component

GO:0005737

cytoplasm

Protein Structure and Domains

PDB ID

MGI:107815

InterPro

IPR003094 Fructose-2,6-bisphosphatase
IPR013078 Histidine phosphatase superfamily, clade-1
IPR013079 6-phosphofructo-2-kinase
IPR013641 Chromatin associated protein KTI12
IPR016260 Bifunctional 6-phosphofructo-2-kinase/fructose-2, 6-bisphosphate 2-phosphatase
IPR027417 P-loop containing nucleoside triphosphate hydrolase
IPR029033 Histidine phosphatase superfamily

PFAM

PF00300
PF01591
PF08433

PRINTS

PR00991

PIRSF

PIRSF000709

SMART

SM00855

TIGRFAMs

Post-translational Modifications

Modification

Cross-References