InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Pfkfb2

Summary

InnateDB Gene

IDBG-190313.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Pfkfb2

Gene Name

6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 2

Synonyms

4930568D07Rik

Species

Mus musculus

Ensembl Gene

ENSMUSG00000026409

Encoded Proteins

IDBP-190315

6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 2

IDBP-626103

6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 2

IDBP-626102

6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 2

IDBP-626105

6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 2

IDBP-788161

6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 2

IDBP-788162

6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 2

IDBP-788165

6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 2

IDBP-788166

6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 2

IDBP-788167

6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 2

IDBP-788171

6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 2

IDBP-788172

6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 2

IDBP-788173

6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 2

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000123836:
The protein encoded by this gene is involved in both the synthesis and degradation of fructose-2,6-bisphosphate, a regulatory molecule that controls glycolysis in eukaryotes. The encoded protein has a 6-phosphofructo-2-kinase activity that catalyzes the synthesis of fructose-2,6-bisphosphate, and a fructose-2,6-biphosphatase activity that catalyzes the degradation of fructose-2,6-bisphosphate. This protein regulates fructose-2,6-bisphosphate levels in the heart, while a related enzyme encoded by a different gene regulates fructose-2,6-bisphosphate levels in the liver and muscle. This enzyme functions as a homodimer. Two transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 1:130689182-130729253

Strand

Reverse strand

Band

Transcripts

ENSMUST00000066863	ENSMUSP00000066426
ENSMUST00000050406	ENSMUSP00000133073
ENSMUST00000171479	ENSMUSP00000129747
ENSMUST00000169659	ENSMUSP00000127587
ENSMUST00000185233	ENSMUSP00000140551
ENSMUST00000187522
ENSMUST00000189534	ENSMUSP00000140355
ENSMUST00000189167	ENSMUSP00000140984
ENSMUST00000187089	ENSMUSP00000140612
ENSMUST00000191347	ENSMUSP00000140698
ENSMUST00000186867	ENSMUSP00000140068
ENSMUST00000191301	ENSMUSP00000140995
ENSMUST00000186777	ENSMUSP00000140799

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 7 interaction(s) predicted by orthology.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	7 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003873	6-phosphofructo-2-kinase activity
GO:0004331	fructose-2,6-bisphosphate 2-phosphatase activity
GO:0005524	ATP binding
GO:0019901	protein kinase binding

Biological Process

GO:0006000	fructose metabolic process
GO:0006003	fructose 2,6-bisphosphate metabolic process
GO:0006007	glucose catabolic process
GO:0006089	lactate metabolic process
GO:0006090	pyruvate metabolic process
GO:0006096	glycolytic process
GO:0009749	response to glucose
GO:0016311	dephosphorylation
GO:0032024	positive regulation of insulin secretion
GO:0033133	positive regulation of glucokinase activity
GO:0046835	carbohydrate phosphorylation