Version 5.4
Mus musculus Protein: Madd
Summary
InnateDB Protein IDBP-190329.5
Last Modified 2012-02-14 [Report errors or provide feedback]
Gene Symbol Madd
Protein Name MAP-kinase activating death domain
Synonyms
Species Mus musculus
Ensembl Protein ENSMUSP00000077094
InnateDB Gene IDBG-190319 (Madd)
Protein Structure
UniProt Annotation
Function
Subcellular Localization
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 9 interaction(s) predicted by orthology.
Experimentally validated
Total 2 [view]
Protein-Protein 2 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 9 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0017112 Rab guanyl-nucleotide exchange factor activity
Biological Process
GO:0000187 activation of MAPK activity
GO:0032483 regulation of Rab protein signal transduction
GO:0032851 positive regulation of Rab GTPase activity
GO:0042981 regulation of apoptotic process
GO:0051726 regulation of cell cycle
GO:0097194 execution phase of apoptosis
GO:1902041 regulation of extrinsic apoptotic signaling pathway via death domain receptors
GO:2001234 negative regulation of apoptotic signaling pathway
GO:2001236 regulation of extrinsic apoptotic signaling pathway
Cellular Component
GO:0005886 plasma membrane
GO:0016021 integral component of membrane
Protein Structure and Domains
PDB ID MGI:2444672
InterPro IPR001194 DENN domain
IPR005112 dDENN domain
IPR005113 uDENN domain
PFAM PF02141
PF03455
PF03456
PRINTS
PIRSF
SMART SM00799
SM00801
SM00800
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt
PhosphoSite PhosphoSite-
TrEMBL A2AGQ4
UniProt Splice Variant
Entrez Gene 228355
UniGene Mm.36410
RefSeq XP_006499285
MGI ID
MGI Symbol Madd
OMIM
CCDS
HPRD
IMGT
EMBL AL691450
GenPept

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca