Version 5.4
Mus musculus Gene: Madd
Summary
InnateDB Gene IDBG-190319.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Madd
Gene Name MAP-kinase activating death domain
Synonyms
Species Mus musculus
Ensembl Gene ENSMUSG00000040687
Encoded Proteins
IDBP-190321
MAP-kinase activating death domain
IDBP-190325
MAP-kinase activating death domain
IDBP-190327
MAP-kinase activating death domain
IDBP-190329
MAP-kinase activating death domain
IDBP-190331
MAP-kinase activating death domain
IDBP-190333
MAP-kinase activating death domain
IDBP-258143
MAP-kinase activating death domain
IDBP-258145
MAP-kinase activating death domain
IDBP-258147
MAP-kinase activating death domain
IDBP-258149
MAP-kinase activating death domain
IDBP-258151
MAP-kinase activating death domain
IDBP-258153
MAP-kinase activating death domain
IDBP-258155
MAP-kinase activating death domain
IDBP-258157
MAP-kinase activating death domain
IDBP-531687
MAP-kinase activating death domain
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000110514:
Tumor necrosis factor alpha (TNF-alpha) is a signaling molecule that interacts with one of two receptors on cells targeted for apoptosis. The apoptotic signal is transduced inside these cells by cytoplasmic adaptor proteins. The protein encoded by this gene is a death domain-containing adaptor protein that interacts with the death domain of TNF-alpha receptor 1 to activate mitogen-activated protein kinase (MAPK) and propagate the apoptotic signal. It is membrane-bound and expressed at a higher level in neoplastic cells than in normal cells. Several transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 2:91137360-91183837
Strand Reverse strand
Band E1
Transcripts
ENSMUST00000099725 ENSMUSP00000097313
ENSMUST00000075269 ENSMUSP00000074746
ENSMUST00000066473 ENSMUSP00000069350
ENSMUST00000077941 ENSMUSP00000077094
ENSMUST00000099723 ENSMUSP00000097311
ENSMUST00000066420 ENSMUSP00000067210
ENSMUST00000111381 ENSMUSP00000107012
ENSMUST00000111376 ENSMUSP00000107007
ENSMUST00000111375 ENSMUSP00000107006
ENSMUST00000111373 ENSMUSP00000107004
ENSMUST00000111372 ENSMUSP00000107003
ENSMUST00000111371 ENSMUSP00000107002
ENSMUST00000111370 ENSMUSP00000107001
ENSMUST00000111369 ENSMUSP00000107000
ENSMUST00000154028
ENSMUST00000150461
ENSMUST00000125321
ENSMUST00000153688
ENSMUST00000125227
ENSMUST00000156368
ENSMUST00000130591
ENSMUST00000135910
ENSMUST00000132791
ENSMUST00000146097
ENSMUST00000130395
ENSMUST00000140600 ENSMUSP00000117657
ENSMUST00000135715
ENSMUST00000150517
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 9 interaction(s) predicted by orthology.
Experimentally validated
Total 2 [view]
Protein-Protein 2 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 9 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0017112 Rab guanyl-nucleotide exchange factor activity
Biological Process
GO:0000187 activation of MAPK activity
GO:0032313 regulation of Rab GTPase activity
GO:0032483 regulation of Rab protein signal transduction
GO:0032851 positive regulation of Rab GTPase activity
GO:0042981 regulation of apoptotic process
GO:0051726 regulation of cell cycle
GO:0097194 execution phase of apoptosis
GO:1902041 regulation of extrinsic apoptotic signaling pathway via death domain receptors
GO:2001234 negative regulation of apoptotic signaling pathway
GO:2001236 regulation of extrinsic apoptotic signaling pathway
Cellular Component
GO:0005737 cytoplasm
GO:0005886 plasma membrane
GO:0016021 integral component of membrane
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000110514
View Gene Order
ENSBTAG00000021700
Not yet available
Pathway Predictions based on Human Orthology Data
NETPATH
NetPath_9
TNFalpha pathway
NetPath_24
TSLP pathway
REACTOME
KEGG
INOH
PID NCI
ceramide_pathway
Ceramide signaling pathway
caspase_pathway
Caspase Cascade in Apoptosis
tnfpathway
TNF receptor signaling pathway
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Mm.36410
RefSeq NM_001177719 NM_001177720 NM_145527 XM_006499229 XM_006499235 XM_006499236 XM_006499237 XM_006499238 XM_006499239
OMIM
CCDS CCDS38178 CCDS50635 CCDS50638
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca