InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Pus1

Summary

InnateDB Protein

IDBP-190354.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Pus1

Protein Name

pseudouridine synthase 1

Synonyms

A730013B20Rik; MPUS1; mPus1p;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000031483

InnateDB Gene

IDBG-190350 (Pus1)

Protein Structure

UniProt Annotation

Function

Converts specific uridines to PSI in a number of tRNA substrates. Acts on positions 27/28 in the anticodon stem and also positions 34 and 36 in the anticodon of an intron containing tRNA. Involved in regulation of nuclear receptor activity possibly through pseudouridylation of SRA1 RNA. Isoforms 3 and 4 do not form pseudouridine when expressed in vitro. {ECO:0000269PubMed:10094309, ECO:0000269PubMed:11085940, ECO:0000269PubMed:15327771}.

Subcellular Localization

Isoform 1: Mitochondrion {ECO:0000250}.Isoform 2: Nucleus {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.

Experimentally validated
Total	3 [view]
Protein-Protein	2 [view]
Protein-DNA	0
Protein-RNA	1 [view]
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	5 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003723	RNA binding
GO:0005515	protein binding
GO:0009982	pseudouridine synthase activity
GO:0030374	ligand-dependent nuclear receptor transcription coactivator activity

Biological Process

GO:0001522	pseudouridine synthesis
GO:0009451	RNA modification
GO:0031119	tRNA pseudouridine synthesis
GO:0045944	positive regulation of transcription from RNA polymerase II promoter

Cellular Component

GO:0000790	nuclear chromatin
GO:0005634	nucleus
GO:0005667	transcription factor complex
GO:0005730	nucleolus
GO:0005739	mitochondrion

Protein Structure and Domains

PDB ID

MGI:1929237

InterPro

IPR001406 Pseudouridine synthase I, TruA
IPR020097 Pseudouridine synthase I, TruA, alpha/beta domain
IPR020103 Pseudouridine synthase, catalytic domain

PFAM

PF01416

PRINTS

PIRSF

PIRSF001430

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q9WU56