Version 5.4
Mus musculus Gene: Pus1
Summary
InnateDB Gene IDBG-190350.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Pus1
Gene Name pseudouridine synthase 1
Synonyms A730013B20Rik; MPUS1; mPus1p
Species Mus musculus
Ensembl Gene ENSMUSG00000029507
Encoded Proteins
IDBP-190352
pseudouridine synthase 1
IDBP-190354
pseudouridine synthase 1
IDBP-190358
pseudouridine synthase 1
IDBP-256061
pseudouridine synthase 1
IDBP-539982
pseudouridine synthase 1
IDBP-539646
pseudouridine synthase 1
IDBP-621373
pseudouridine synthase 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000177192:
This gene encodes a pseudouridine synthase that converts uridine to pseudouridine once it has been incorporated into an RNA molecule. The encoded enzyme may play an essential role in tRNA function and in stabilizing the secondary and tertiary structure of many RNAs. A mutation in this gene has been linked to mitochondrial myopathy and sideroblastic anemia. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Sep 2009]
Gene Information
Type Protein coding
Genomic Location Chromosome 5:110773667-110780659
Strand Reverse strand
Band F
Transcripts
ENSMUST00000086643 ENSMUSP00000083844
ENSMUST00000031483 ENSMUSP00000031483
ENSMUST00000031481 ENSMUSP00000031481
ENSMUST00000112426 ENSMUSP00000108045
ENSMUST00000136483 ENSMUSP00000115143
ENSMUST00000149208 ENSMUSP00000115468
ENSMUST00000170468 ENSMUSP00000130814
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.
Experimentally validated
Total 3 [view]
Protein-Protein 2 [view]
Protein-DNA 0
Protein-RNA 1 [view]
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 5 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003723 RNA binding
GO:0005515 protein binding
GO:0009982 pseudouridine synthase activity
GO:0030374 ligand-dependent nuclear receptor transcription coactivator activity
GO:0044822 poly(A) RNA binding
Biological Process
GO:0001522 pseudouridine synthesis
GO:0009451 RNA modification
GO:0031119 tRNA pseudouridine synthesis
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
Cellular Component
GO:0000790 nuclear chromatin
GO:0005634 nucleus
GO:0005667 transcription factor complex
GO:0005730 nucleolus
GO:0005739 mitochondrion
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000177192
View Gene Order
ENSBTAG00000012990
Not yet available
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Mm.23528
RefSeq NM_001025561 NM_001025562 NM_019700 XM_006535148 XM_006535149
OMIM
CCDS CCDS19530 CCDS19531 CCDS39212
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca