Version 5.4
Mus musculus Protein: Mthfs
Summary
InnateDB Protein IDBP-190402.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Mthfs
Protein Name 5, 10-methenyltetrahydrofolate synthetase
Synonyms 1110034I12Rik; 2310020H23Rik; AI119695;
Species Mus musculus
Ensembl Protein ENSMUSP00000082354
InnateDB Gene IDBG-190400 (Mthfs)
Protein Structure
UniProt Annotation
Function Contributes to tetrahydrofolate metabolism. Helps regulate carbon flow through the folate-dependent one-carbon metabolic network that supplies carbon for the biosynthesis of purines, thymidine and amino acids. Catalyzes the irreversible conversion of 5-formyltetrahydrofolate (5-CHO-H(4)PteGlu) to yield 5,10-methenyltetrahydrofolate (By similarity). {ECO:0000250}.
Subcellular Localization Cytoplasm {ECO:0000250}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
Experimentally validated
Total 2 [view]
Protein-Protein 2 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005524 ATP binding
GO:0005542 folic acid binding
GO:0030272 5-formyltetrahydrofolate cyclo-ligase activity
Biological Process
GO:0009396 folic acid-containing compound biosynthetic process
GO:0046653 tetrahydrofolate metabolic process
Cellular Component
GO:0005739 mitochondrion
Protein Structure and Domains
PDB ID MGI:1340032
InterPro IPR002698 5-formyltetrahydrofolate cyclo-ligase
PFAM PF01812
PRINTS
PIRSF PIRSF006806
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9D110
PhosphoSite PhosphoSite-Q9D110
TrEMBL D3Z0T4
UniProt Splice Variant
Entrez Gene 107885
UniGene Mm.486274
RefSeq NP_081105
MGI ID
MGI Symbol Mthfs
OMIM
CCDS CCDS23394
HPRD
IMGT
EMBL AC135634 AK004092 CT030686
GenPept BAB23165 CAQ52322

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca