InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: PLIN5

Summary

InnateDB Protein

IDBP-19052.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

PLIN5

Protein Name

perilipin 5

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000371272

InnateDB Gene

IDBG-233258 (PLIN5)

Protein Structure

UniProt Annotation

Function

Lipid droplet-associated protein that maintains the balance between lipogenesis and lipolysis and also regulates fatty acid oxidation in oxidative tissues. Recruits mitochondria to the surface of lipid droplets and is involved in lipid droplet homeostasis by regulating both the storage of fatty acids in the form of triglycerides and the release of fatty acids for mitochondrial fatty acid oxidation. In lipid droplet triacylglycerol hydrolysis, plays a role as a scaffolding protein for three major key lipolytic players: ABHD5, PNPLA2 and LIPE. Reduces the triacylglycerol hydrolase activity of PNPLA2 by recruiting and sequestering PNPLA2 to lipid droplets. Phosphorylation by PKA enables lipolysis probably by promoting release of ABHD5 from the perilipin scaffold and by facilitating interaction of ABHD5 with PNPLA2. Also increases lipolysis through interaction with LIPE and upon PKA-mediated phosphorylation of LIPE (By similarity). {ECO:0000250}.

Subcellular Localization

Lipid droplet {ECO:0000269PubMed:17234449}. Cytoplasm {ECO:0000250}. Mitochondrion {ECO:0000250}. Note=Lipid droplet surface-associated. Exchanges between lipid droplets and the cytoplasm (By similarity). {ECO:0000250}.

Disease Associations

Tissue Specificity

Expressed in skeletal muscle, liver, heart and kidney. {ECO:0000269PubMed:17234449}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0035473	lipase binding
GO:0042802	identical protein binding

Biological Process

GO:0010867	positive regulation of triglyceride biosynthetic process
GO:0010884	positive regulation of lipid storage
GO:0010890	positive regulation of sequestering of triglyceride
GO:0010897	negative regulation of triglyceride catabolic process
GO:0019915	lipid storage
GO:0031999	negative regulation of fatty acid beta-oxidation
GO:0032000	positive regulation of fatty acid beta-oxidation
GO:0034389	lipid particle organization
GO:0035359	negative regulation of peroxisome proliferator activated receptor signaling pathway
GO:0050995	negative regulation of lipid catabolic process
GO:0051646	mitochondrion localization
GO:0060192	negative regulation of lipase activity
GO:0060193	positive regulation of lipase activity
GO:2000378	negative regulation of reactive oxygen species metabolic process