InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Nfat5

Summary

InnateDB Protein

IDBP-190691.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Nfat5

Protein Name

nuclear factor of activated T-cells 5

Synonyms

AI225870; B130038B15Rik; CAG-8; CAG80; mKIAA0827; NFATL1; nfatz; OREBP; TonEBP;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000075311

InnateDB Gene

IDBG-190689 (Nfat5)

Protein Structure

UniProt Annotation

Function

Transcription factor involved in the transcriptional regulation of osmoprotective and inflammatory genes. Regulates hypertonicity-induced cellular accumulation of osmolytes. {ECO:0000269PubMed:11934689, ECO:0000269PubMed:14983020}.

Subcellular Localization

Nucleus {ECO:0000269PubMed:11934689}. Cytoplasm {ECO:0000269PubMed:11934689}. Note=Nuclear distribution increases under hypertonic conditions.

Disease Associations

Tissue Specificity

Detected in white and brown adipose tissue, muscle, heart, liver and kidney. Expressed in lymphocytes (at protein level). {ECO:0000269PubMed:14983020, ECO:0000269PubMed:23233732}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 13 experimentally validated interaction(s) in this database.
They are also associated with 15 interaction(s) predicted by orthology.

Experimentally validated
Total	13 [view]
Protein-Protein	1 [view]
Protein-DNA	12 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	15 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003677	DNA binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0005515	protein binding

Biological Process

GO:0001816	cytokine production
GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0010628	positive regulation of gene expression
GO:0045087	innate immune response (InnateDB)
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0070884	regulation of calcineurin-NFAT signaling cascade

Cellular Component

GO:0005634	nucleus
GO:0005737	cytoplasm

Protein Structure and Domains

PDB ID

MGI:1859333

InterPro

IPR002909 IPT domain
IPR008366 Nuclear factor of activated T cells (NFAT)
IPR008967 p53-like transcription factor, DNA-binding
IPR011539 Rel homology domain
IPR014756 Immunoglobulin E-set

PFAM

PF01833
PF00554

PRINTS

PR01789

PIRSF

SMART

SM00429

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt