InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Sync

Summary

InnateDB Protein

IDBP-190750.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Sync

Protein Name

syncoilin

Synonyms

1110057H03Rik; SNIP4;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000099659

InnateDB Gene

IDBG-190748 (Sync)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Cytoplasm, perinuclear region {ECO:0000269PubMed:11053421, ECO:0000269PubMed:11694502, ECO:0000269PubMed:17629480}. Note=In skeletal muscle, colocalizes with DES and DTNA, and is localized at the myotendinous and neuromuscular junctions, sarcolemma and Z-lines. In myotubes, detected in a punctate cytoplasmic pattern. {ECO:0000269PubMed:11053421, ECO:0000269PubMed:11694502, ECO:0000269PubMed:17629480}.

Disease Associations

Tissue Specificity

Detected strongly in skeletal muscle and heart and weakly in lung (at protein level). Highly expressed in skeletal muscle and lung and weakly in lung and testis. {ECO:0000269PubMed:11053421}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 7 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	7 [view]
Protein-Protein	7 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005198	structural molecule activity
GO:0005515	protein binding

Biological Process

GO:0045103

intermediate filament-based process

Cellular Component

GO:0005737	cytoplasm
GO:0005829	cytosol
GO:0005882	intermediate filament
GO:0030018	Z disc
GO:0031594	neuromuscular junction
GO:0042383	sarcolemma
GO:0048471	perinuclear region of cytoplasm